Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2956417..2957077 Replicon chromosome
Accession NZ_CP020817
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name higB Uniprot ID A0A808IFD9
Locus tag B7P19_RS14440 Protein ID WP_048980127.1
Coordinates 2956724..2957077 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z3MX79
Locus tag B7P19_RS14435 Protein ID WP_029741460.1
Coordinates 2956417..2956719 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7P19_RS14415 2952394..2954583 + 2190 WP_045356712.1 TonB-dependent siderophore receptor -
B7P19_RS14425 2954878..2955279 - 402 WP_048980122.1 RidA family protein -
B7P19_RS14430 2955421..2956341 + 921 WP_048980124.1 LysR family transcriptional regulator -
B7P19_RS14435 2956417..2956719 - 303 WP_029741460.1 XRE family transcriptional regulator Antitoxin
B7P19_RS14440 2956724..2957077 - 354 WP_048980127.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7P19_RS14445 2957255..2958148 - 894 WP_048980130.1 LysR family transcriptional regulator -
B7P19_RS14450 2958319..2958927 + 609 WP_080973612.1 glutathione S-transferase family protein -
B7P19_RS14455 2958971..2959921 - 951 WP_023336219.1 HTH-type transcriptional regulator Cbl -
B7P19_RS14460 2960018..2960935 - 918 WP_033145933.1 nitrogen assimilation transcriptional regulator NAC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13599.44 Da        Isoelectric Point: 8.9620

>T75436 WP_048980127.1 NZ_CP020817:c2957077-2956724 [Enterobacter sp. Crenshaw]
VWAINTTDRFDRWFTSLDDTDRASVLAALLVLREKGPGLSRPYADTLKGSRYSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLDRLKERE

Download         Length: 354 bp

>T75436 NZ_CP020817:c2957077-2956724 [Enterobacter sp. Crenshaw]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGATCGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGGATAGATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11050.83 Da        Isoelectric Point: 5.7316

>AT75436 WP_029741460.1 NZ_CP020817:c2956719-2956417 [Enterobacter sp. Crenshaw]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT75436 NZ_CP020817:c2956719-2956417 [Enterobacter sp. Crenshaw]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCTGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808IFD9

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MX79

References