Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4204038..4204747 Replicon chromosome
Accession NZ_CP020809
Organism Mycobacterium dioxanotrophicus strain PH-06

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag BTO20_RS20395 Protein ID WP_087078027.1
Coordinates 4204346..4204747 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag BTO20_RS20390 Protein ID WP_087078026.1
Coordinates 4204038..4204349 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTO20_RS20375 4199587..4201788 - 2202 WP_087078023.1 helix-turn-helix domain-containing protein -
BTO20_RS20380 4202546..4202953 - 408 WP_087078024.1 hypothetical protein -
BTO20_RS20385 4203148..4203975 + 828 WP_157680277.1 hypothetical protein -
BTO20_RS20390 4204038..4204349 - 312 WP_087078026.1 helix-turn-helix transcriptional regulator Antitoxin
BTO20_RS20395 4204346..4204747 - 402 WP_087078027.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTO20_RS20400 4204860..4206263 + 1404 WP_087078028.1 hypothetical protein -
BTO20_RS20405 4206346..4206783 + 438 WP_087078029.1 hypothetical protein -
BTO20_RS39450 4206813..4206962 - 150 WP_157680278.1 hypothetical protein -
BTO20_RS39455 4206990..4207199 - 210 WP_157680279.1 hypothetical protein -
BTO20_RS20410 4207445..4207786 + 342 WP_087078030.1 hypothetical protein -
BTO20_RS20415 4207816..4208412 + 597 WP_087078031.1 hypothetical protein -
BTO20_RS20420 4208452..4208790 + 339 WP_087078032.1 hypothetical protein -
BTO20_RS20425 4208792..4209730 + 939 WP_087078033.1 C40 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-111)

Antitoxin

HigA2-like, helix-turn-helix domain

(28-92)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15508.51 Da        Isoelectric Point: 10.6626

>T75419 WP_087078027.1 NZ_CP020809:c4204747-4204346 [Mycobacterium dioxanotrophicus]
VPTRRWEVDTTLIHDWIIGLDEATQDSVLSALEYLANNGPTAGRPFVDRIHHSRHQNMKELRPRSPGGSRQLRILFAFDL
QSHAITLIAGDKTGDWNKWYRDNVPAADDLFDRHLERTTEKKKQKKQRKGKRR

Download         Length: 402 bp

>T75419 NZ_CP020809:c4204747-4204346 [Mycobacterium dioxanotrophicus]
GTGCCGACGCGACGGTGGGAGGTGGACACGACACTGATCCACGACTGGATCATCGGCTTGGACGAAGCCACGCAGGACAG
CGTCCTGTCGGCGTTGGAGTACTTGGCCAACAACGGCCCCACCGCGGGTCGACCGTTCGTGGACCGCATCCACCACTCGC
GGCACCAGAACATGAAAGAGTTGCGCCCGCGCAGCCCCGGCGGAAGCCGGCAGTTGCGCATCCTGTTCGCGTTCGACCTG
CAATCGCACGCGATCACACTGATCGCCGGTGACAAGACCGGCGACTGGAACAAGTGGTACCGGGACAACGTTCCGGCGGC
GGACGATCTATTCGACCGGCACCTGGAACGGACTACCGAGAAGAAGAAACAGAAGAAGCAGCGGAAGGGGAAGAGACGAT
GA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11374.02 Da        Isoelectric Point: 7.0168

>AT75419 WP_087078026.1 NZ_CP020809:c4204349-4204038 [Mycobacterium dioxanotrophicus]
MSTLDELLSGLPVERRERIARGAAEMEREAAEYRLRQLREDAGYTQKALAVLIGVGQNRVSQMEHGQIAAAQVSTLRKYV
EATGGELELVVKRPDGTRIPLAI

Download         Length: 312 bp

>AT75419 NZ_CP020809:c4204349-4204038 [Mycobacterium dioxanotrophicus]
ATGAGCACACTCGACGAACTACTGTCCGGTCTGCCCGTGGAGCGTCGCGAACGCATCGCCCGCGGCGCCGCCGAGATGGA
GCGCGAGGCAGCCGAGTACCGCCTCCGCCAGCTTCGTGAGGACGCCGGCTACACGCAGAAGGCCCTCGCCGTGCTCATCG
GCGTCGGCCAGAACAGGGTCTCCCAGATGGAGCACGGGCAGATCGCCGCCGCGCAGGTGTCGACCTTGCGCAAGTACGTC
GAGGCTACCGGCGGTGAGTTGGAGCTGGTGGTCAAGCGCCCCGACGGGACCCGCATCCCGCTGGCGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References