Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2080739..2080964 Replicon chromosome
Accession NZ_CP020753
Organism Shigella flexneri 1c strain Y394

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag B7485_RS11085 Protein ID WP_000813254.1
Coordinates 2080739..2080894 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2080906..2080964 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7485_RS11020 2076172..2076869 + 698 WP_225620329.1 IS1 family transposase -
B7485_RS11025 2076881..2077072 - 192 Protein_2121 helix-turn-helix domain-containing protein -
B7485_RS11030 2077171..2077386 - 216 WP_000839572.1 class II holin family protein -
B7485_RS11060 2078182..2078870 - 689 Protein_2123 bacteriophage antitermination protein Q -
B7485_RS11065 2078867..2079232 - 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
B7485_RS11070 2079233..2080291 - 1059 WP_001265248.1 DUF968 domain-containing protein -
B7485_RS11075 2080293..2080571 - 279 WP_011069426.1 hypothetical protein -
B7485_RS11085 2080739..2080894 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 2080906..2080964 + 59 - - Antitoxin
B7485_RS11100 2081546..2081962 - 417 WP_005069274.1 hypothetical protein -
B7485_RS11105 2081989..2082129 + 141 Protein_2129 DUF4224 domain-containing protein -
B7485_RS11110 2082129..2083179 + 1051 Protein_2130 tyrosine-type recombinase/integrase -
B7485_RS11120 2083390..2084187 + 798 WP_001325918.1 DgsA anti-repressor MtfA -
B7485_RS11130 2084525..2085787 + 1263 Protein_2132 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 / ipaH9.8 2032882..2099491 66609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T75398 WP_000813254.1 NZ_CP020753:c2080894-2080739 [Shigella flexneri 1c]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T75398 NZ_CP020753:c2080894-2080739 [Shigella flexneri 1c]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT75398 NZ_CP020753:2080906-2080964 [Shigella flexneri 1c]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References