Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2055063..2055288 Replicon chromosome
Accession NZ_CP020753
Organism Shigella flexneri 1c strain Y394

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag B7485_RS10855 Protein ID WP_000813254.1
Coordinates 2055063..2055218 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2055230..2055288 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7485_RS10790 2050496..2051193 + 698 WP_225620329.1 IS1 family transposase -
B7485_RS10795 2051205..2051396 - 192 Protein_2089 helix-turn-helix domain-containing protein -
B7485_RS10800 2051495..2051710 - 216 WP_000839572.1 class II holin family protein -
B7485_RS10830 2052506..2053194 - 689 Protein_2091 bacteriophage antitermination protein Q -
B7485_RS10835 2053191..2053556 - 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
B7485_RS10840 2053557..2054615 - 1059 WP_001265248.1 DUF968 domain-containing protein -
B7485_RS10845 2054617..2054895 - 279 WP_011069426.1 hypothetical protein -
B7485_RS10855 2055063..2055218 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 2055230..2055288 + 59 - - Antitoxin
B7485_RS10870 2055870..2056286 - 417 WP_005069274.1 hypothetical protein -
B7485_RS10875 2056313..2056453 + 141 Protein_2097 DUF4224 domain-containing protein -
B7485_RS10880 2056453..2057503 + 1051 Protein_2098 tyrosine-type recombinase/integrase -
B7485_RS10890 2057714..2058511 + 798 WP_001325918.1 DgsA anti-repressor MtfA -
B7485_RS10900 2058849..2060111 + 1263 Protein_2100 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 / ipaH9.8 2032882..2099491 66609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T75396 WP_000813254.1 NZ_CP020753:c2055218-2055063 [Shigella flexneri 1c]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T75396 NZ_CP020753:c2055218-2055063 [Shigella flexneri 1c]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT75396 NZ_CP020753:2055230-2055288 [Shigella flexneri 1c]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References