Detailed information of TA system TA075366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 430279..430906
• Replicon: chromosome
• Accession: NZ_CP020742
• Organism: Bartonella henselae strain Houston-I

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: BhenCHDE101_RS01795
• Protein ID: WP_011180277.1
• Coordinates: 430279..430593 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: BhenCHDE101_RS01800
• Protein ID: WP_011180278.1
• Coordinates: 430610..430906 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BhenCHDE101_RS01775	425906..427462	-	1557	WP_011180273.1	phage portal protein	-
BhenCHDE101_RS01780	427462..427710	-	249	WP_011180274.1	hypothetical protein	-
BhenCHDE101_RS01785	427714..429642	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
BhenCHDE101_RS01790	429635..430216	-	582	WP_011180276.1	hypothetical protein	-
BhenCHDE101_RS01795	430279..430593	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BhenCHDE101_RS01800	430610..430906	+	297	WP_011180278.1	HigA family addiction module antidote protein	Antitoxin
BhenCHDE101_RS01805	431316..431579	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
BhenCHDE101_RS01810	431566..431847	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
BhenCHDE101_RS01815	431890..432168	-	279	WP_011180242.1	hypothetical protein	-
BhenCHDE101_RS01820	432165..432923	-	759	WP_011180282.1	phage antirepressor Ant	-
BhenCHDE101_RS01825	432983..433498	-	516	WP_011180283.1	phage antirepressor Ant	-
BhenCHDE101_RS01830	433791..434354	-	564	Protein_346	antA/AntB antirepressor family protein	-
BhenCHDE101_RS01835	434386..434928	-	543	WP_011180285.1	phage antirepressor Ant	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	386552..456213	69661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T75366 WP_011180277.1 NZ_CP020742:430279-430593 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T75366 NZ_CP020742:430279-430593 [Bartonella henselae]
ATGATACATAAAAGAACGAATGAAGGTGACTTGGTAATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAATCCACCTAAAGGTTTTCCCACAACTCTCGTGCGTATAGTCCAACGAAAATTATTTATGCTGGATAAAGCAGTTGATC
TCAAAGATTTACGCAGTCCTCCGGGTAATCGTTTAGAGGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGCATTTGTTTTGAGTGGCGTTCTAATGGTGCCTATGAAGTTGAAATCGTCGATTATCATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT75366 WP_011180278.1 NZ_CP020742:430610-430906 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT75366 NZ_CP020742:430610-430906 [Bartonella henselae]
ATGAAAAATTATATTGCTATTCATCCCGGAGAAATTTTACGGGAAGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
TCTTGCCAAAGCCTTGAATGTTCCACGCACTCGGATAGAACGGATTGTAGCAGAAAATAGTCGGATAACTCCTGATACAG
CACTACGATTAGCCTCTTTTTTTGATACAACAGCTGAATTCTGGCTCAACATGCAAGCTGCTTACGATGTCAGTGTCTTA
CAAGCTGAAAAAGCAGATGAATTTTCCAAAATTAGTAAATTTGAATGTAGAGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0