Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/- |
Location | 1586226..1586640 | Replicon | chromosome |
Accession | NZ_CP020741 | ||
Organism | Staphylococcus aureus strain HZW450 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | B7437_RS07830 | Protein ID | WP_001065099.1 |
Coordinates | 1586389..1586640 (-) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | B7437_RS14635 | Protein ID | WP_000028424.1 |
Coordinates | 1586226..1586399 (-) | Length | 58 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
B7437_RS07775 | 1582008..1582352 | - | 345 | WP_000402904.1 | hypothetical protein | - |
B7437_RS07780 | 1582483..1582782 | - | 300 | WP_000988330.1 | HNH endonuclease | - |
B7437_RS07785 | 1583014..1583430 | - | 417 | WP_000590122.1 | hypothetical protein | - |
B7437_RS07790 | 1583458..1583658 | - | 201 | WP_000265043.1 | DUF1514 family protein | - |
B7437_RS07795 | 1583658..1584308 | - | 651 | WP_001005262.1 | hypothetical protein | - |
B7437_RS07800 | 1584467..1584616 | - | 150 | WP_000237868.1 | transcriptional activator RinB | - |
B7437_RS07805 | 1584619..1584819 | - | 201 | WP_001125015.1 | hypothetical protein | - |
B7437_RS07810 | 1584794..1584982 | - | 189 | WP_000195782.1 | DUF1381 domain-containing protein | - |
B7437_RS07815 | 1584979..1585224 | - | 246 | WP_001282074.1 | hypothetical protein | - |
B7437_RS07820 | 1585261..1585767 | - | 507 | WP_001061834.1 | dUTPase | - |
B7437_RS14630 | 1585782..1585943 | - | 162 | WP_000889683.1 | hypothetical protein | - |
B7437_RS07825 | 1585944..1586225 | - | 282 | WP_000454994.1 | hypothetical protein | - |
B7437_RS14635 | 1586226..1586399 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
B7437_RS07830 | 1586389..1586640 | - | 252 | WP_001065099.1 | DUF1024 family protein | Toxin |
B7437_RS07835 | 1586655..1586897 | - | 243 | WP_000131388.1 | phi PVL orf 51-like protein | - |
B7437_RS07840 | 1586901..1587257 | - | 357 | WP_000029366.1 | hypothetical protein | - |
B7437_RS07845 | 1587258..1587443 | - | 186 | WP_001187236.1 | DUF3113 family protein | - |
B7437_RS07850 | 1587448..1587852 | - | 405 | WP_000049798.1 | DUF1064 domain-containing protein | - |
B7437_RS07855 | 1587862..1588083 | - | 222 | WP_001123669.1 | DUF3269 family protein | - |
B7437_RS07860 | 1588096..1588254 | - | 159 | WP_000256594.1 | hypothetical protein | - |
B7437_RS07865 | 1588248..1589027 | - | 780 | WP_000803062.1 | ATP-binding protein | - |
B7437_RS07870 | 1589037..1589807 | - | 771 | WP_000190254.1 | conserved phage C-terminal domain-containing protein | - |
B7437_RS07875 | 1589873..1590154 | + | 282 | WP_000414755.1 | hypothetical protein | - |
B7437_RS14640 | 1590147..1590296 | - | 150 | WP_001081076.1 | hypothetical protein | - |
B7437_RS07880 | 1590293..1590967 | - | 675 | WP_000057262.1 | hypothetical protein | - |
B7437_RS07885 | 1590979..1591422 | - | 444 | WP_001099007.1 | single-stranded DNA-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | lukF-PV / lukS-PV | 1554690..1618499 | 63809 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9376.32 Da Isoelectric Point: 3.8364
>T75358 WP_001065099.1 NZ_CP020741:c1586640-1586389 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T75358 NZ_CP020741:c1586640-1586389 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT75358 WP_000028424.1 NZ_CP020741:c1586399-1586226 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT75358 NZ_CP020741:c1586399-1586226 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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