Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1586226..1586640 Replicon chromosome
Accession NZ_CP020741
Organism Staphylococcus aureus strain HZW450

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B7437_RS07830 Protein ID WP_001065099.1
Coordinates 1586389..1586640 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B7437_RS14635 Protein ID WP_000028424.1
Coordinates 1586226..1586399 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7437_RS07775 1582008..1582352 - 345 WP_000402904.1 hypothetical protein -
B7437_RS07780 1582483..1582782 - 300 WP_000988330.1 HNH endonuclease -
B7437_RS07785 1583014..1583430 - 417 WP_000590122.1 hypothetical protein -
B7437_RS07790 1583458..1583658 - 201 WP_000265043.1 DUF1514 family protein -
B7437_RS07795 1583658..1584308 - 651 WP_001005262.1 hypothetical protein -
B7437_RS07800 1584467..1584616 - 150 WP_000237868.1 transcriptional activator RinB -
B7437_RS07805 1584619..1584819 - 201 WP_001125015.1 hypothetical protein -
B7437_RS07810 1584794..1584982 - 189 WP_000195782.1 DUF1381 domain-containing protein -
B7437_RS07815 1584979..1585224 - 246 WP_001282074.1 hypothetical protein -
B7437_RS07820 1585261..1585767 - 507 WP_001061834.1 dUTPase -
B7437_RS14630 1585782..1585943 - 162 WP_000889683.1 hypothetical protein -
B7437_RS07825 1585944..1586225 - 282 WP_000454994.1 hypothetical protein -
B7437_RS14635 1586226..1586399 - 174 WP_000028424.1 hypothetical protein Antitoxin
B7437_RS07830 1586389..1586640 - 252 WP_001065099.1 DUF1024 family protein Toxin
B7437_RS07835 1586655..1586897 - 243 WP_000131388.1 phi PVL orf 51-like protein -
B7437_RS07840 1586901..1587257 - 357 WP_000029366.1 hypothetical protein -
B7437_RS07845 1587258..1587443 - 186 WP_001187236.1 DUF3113 family protein -
B7437_RS07850 1587448..1587852 - 405 WP_000049798.1 DUF1064 domain-containing protein -
B7437_RS07855 1587862..1588083 - 222 WP_001123669.1 DUF3269 family protein -
B7437_RS07860 1588096..1588254 - 159 WP_000256594.1 hypothetical protein -
B7437_RS07865 1588248..1589027 - 780 WP_000803062.1 ATP-binding protein -
B7437_RS07870 1589037..1589807 - 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
B7437_RS07875 1589873..1590154 + 282 WP_000414755.1 hypothetical protein -
B7437_RS14640 1590147..1590296 - 150 WP_001081076.1 hypothetical protein -
B7437_RS07880 1590293..1590967 - 675 WP_000057262.1 hypothetical protein -
B7437_RS07885 1590979..1591422 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1554690..1618499 63809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T75358 WP_001065099.1 NZ_CP020741:c1586640-1586389 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T75358 NZ_CP020741:c1586640-1586389 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT75358 WP_000028424.1 NZ_CP020741:c1586399-1586226 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT75358 NZ_CP020741:c1586399-1586226 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References