Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2532611..2533299 Replicon chromosome
Accession NZ_CP020715
Organism Cnuibacter physcomitrellae strain XA(T)

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag B5808_RS11870 Protein ID WP_085019982.1
Coordinates 2532922..2533299 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag B5808_RS11865 Protein ID WP_085021485.1
Coordinates 2532611..2532916 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5808_RS11845 2527612..2528829 - 1218 WP_085019978.1 alanine--glyoxylate aminotransferase family protein -
B5808_RS11850 2528961..2530532 - 1572 WP_085019979.1 DUF3225 domain-containing protein -
B5808_RS11855 2530525..2531604 - 1080 WP_085019980.1 acetamidase/formamidase family protein -
B5808_RS11860 2531663..2532391 + 729 WP_157127461.1 DUF1275 domain-containing protein -
B5808_RS11865 2532611..2532916 - 306 WP_085021485.1 helix-turn-helix transcriptional regulator Antitoxin
B5808_RS11870 2532922..2533299 - 378 WP_085019982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5808_RS11875 2533420..2534433 - 1014 WP_085019983.1 Fpg/Nei family DNA glycosylase -
B5808_RS11880 2534435..2535169 - 735 WP_085019984.1 ribonuclease III -
B5808_RS11885 2535216..2535419 - 204 WP_085019985.1 50S ribosomal protein L32 -
B5808_RS11890 2535493..2536008 - 516 WP_085021486.1 DUF177 domain-containing protein -
B5808_RS11895 2536045..2536983 - 939 WP_085019986.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14345.40 Da        Isoelectric Point: 7.2033

>T75344 WP_085019982.1 NZ_CP020715:c2533299-2532922 [Cnuibacter physcomitrellae]
MWTVDLGLIEDWLMDLDDDTYDQVIAAIELLQEHGPQLGRPLVDTVKGSSYKNMKELRPGSSGKSELRVLFAFDPQRQAI
VLVAGDKAGNWKTWYRENIPIADARFTEHLAQMKKQTEKNKTKRK

Download         Length: 378 bp

>T75344 NZ_CP020715:c2533299-2532922 [Cnuibacter physcomitrellae]
ATGTGGACCGTCGACCTCGGGTTGATCGAGGATTGGCTGATGGACCTGGATGACGACACATATGACCAGGTCATCGCTGC
CATCGAACTCCTCCAGGAACACGGCCCACAGCTGGGACGTCCCCTCGTGGACACGGTGAAGGGATCCTCGTACAAGAACA
TGAAGGAGCTTCGACCCGGCTCATCCGGTAAGTCGGAGCTGAGGGTGCTGTTCGCCTTCGATCCCCAGCGACAAGCGATC
GTGCTGGTCGCCGGCGACAAGGCCGGTAACTGGAAGACGTGGTACCGGGAGAACATCCCGATCGCAGACGCTCGTTTCAC
AGAGCATCTGGCCCAGATGAAGAAGCAGACCGAGAAGAACAAGACGAAGAGGAAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11274.88 Da        Isoelectric Point: 9.6179

>AT75344 WP_085021485.1 NZ_CP020715:c2532916-2532611 [Cnuibacter physcomitrellae]
MALTPEQLLEKRPANRARVDAQKERMLGEVRAYRLRELREQLGLSQAQLAERIGVGQRQVSKIENGDLDSARVGTIRKYI
EAVGGDLVVEYVAGDSRLQVA

Download         Length: 306 bp

>AT75344 NZ_CP020715:c2532916-2532611 [Cnuibacter physcomitrellae]
ATGGCTCTTACTCCGGAGCAGCTGCTTGAGAAGCGTCCCGCGAACCGTGCACGTGTCGACGCGCAGAAGGAGCGGATGCT
GGGCGAGGTGCGGGCGTACCGGCTGCGCGAACTCCGTGAGCAACTCGGACTCAGCCAAGCTCAGCTCGCCGAGCGCATCG
GTGTCGGTCAGCGCCAGGTCTCGAAGATCGAGAACGGCGATCTCGACAGCGCCCGCGTCGGCACGATTCGGAAGTACATC
GAAGCTGTCGGCGGCGACCTCGTCGTCGAGTACGTCGCCGGTGATAGCCGACTGCAGGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References