Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2556789..2557051 Replicon chromosome
Accession NZ_CP020713
Organism Staphylococcus aureus strain K17

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag B7473_RS13270 Protein ID WP_001802298.1
Coordinates 2556947..2557051 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2556789..2556952 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7473_RS13250 2553029..2553694 - 666 WP_001024095.1 SDR family oxidoreductase -
B7473_RS13255 2553846..2554166 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
B7473_RS13260 2554168..2555148 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
B7473_RS13265 2555414..2556505 + 1092 WP_000495681.1 hypothetical protein -
- 2556789..2556952 + 164 - - Antitoxin
B7473_RS13270 2556947..2557051 - 105 WP_001802298.1 hypothetical protein Toxin
B7473_RS13280 2557731..2557889 + 159 WP_001792784.1 hypothetical protein -
B7473_RS13290 2558547..2559404 - 858 WP_000370930.1 Cof-type HAD-IIB family hydrolase -
B7473_RS13295 2559472..2560254 - 783 WP_000908180.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T75323 WP_001802298.1 NZ_CP020713:c2557051-2556947 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T75323 NZ_CP020713:c2557051-2556947 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT75323 NZ_CP020713:2556789-2556952 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References