Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 240159..240676 Replicon chromosome
Accession NZ_CP020713
Organism Staphylococcus aureus strain K17

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag B7473_RS01305 Protein ID WP_000113262.1
Coordinates 240410..240676 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag B7473_RS01300 Protein ID WP_000584499.1
Coordinates 240159..240410 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7473_RS01270 235857..236576 + 720 WP_000479576.1 amino acid ABC transporter permease -
B7473_RS01275 236573..237304 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
B7473_RS01280 237401..238651 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
B7473_RS01285 238906..239268 + 363 WP_000819843.1 DUF4467 domain-containing protein -
B7473_RS01290 239287..239886 + 600 WP_000162813.1 DsbA family protein -
B7473_RS01295 239893..239994 + 102 WP_031774922.1 hypothetical protein -
B7473_RS01300 240159..240410 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B7473_RS01305 240410..240676 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
B7473_RS01310 240972..242522 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
B7473_RS01315 242708..243175 + 468 WP_101766510.1 SRPBCC domain-containing protein -
B7473_RS01320 243259..243441 + 183 WP_000230294.1 hypothetical protein -
B7473_RS01325 243658..244482 + 825 WP_000572040.1 formate/nitrite transporter family protein -
B7473_RS01330 244715..245251 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T75317 WP_000113262.1 NZ_CP020713:240410-240676 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T75317 NZ_CP020713:240410-240676 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT75317 WP_000584499.1 NZ_CP020713:240159-240410 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT75317 NZ_CP020713:240159-240410 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References