Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5910289..5910884 Replicon chromosome
Accession NZ_CP020704
Organism Pseudomonas aeruginosa strain PASGNDM699

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag B7W87_RS28645 Protein ID WP_003113526.1
Coordinates 5910606..5910884 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B7W87_RS28640 Protein ID WP_003133769.1
Coordinates 5910289..5910594 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7W87_RS28610 5905311..5905601 - 291 WP_031757220.1 DUF5447 family protein -
B7W87_RS28615 5905777..5906049 - 273 WP_004352675.1 hypothetical protein -
B7W87_RS28625 5906489..5906824 + 336 WP_023094905.1 hypothetical protein -
B7W87_RS34010 5906918..5907508 + 591 WP_071536478.1 SLATT domain-containing protein -
B7W87_RS28630 5907505..5908770 + 1266 WP_023094906.1 nucleotidyltransferase -
B7W87_RS28635 5908854..5909846 - 993 WP_003133766.1 hypothetical protein -
B7W87_RS28640 5910289..5910594 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
B7W87_RS28645 5910606..5910884 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7W87_RS28655 5911213..5913441 + 2229 WP_003133778.1 TonB-dependent receptor -
B7W87_RS28660 5913512..5914159 - 648 WP_003095021.1 carbonate dehydratase -
B7W87_RS28665 5914221..5915459 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T75313 WP_003113526.1 NZ_CP020704:c5910884-5910606 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T75313 NZ_CP020704:c5910884-5910606 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT75313 WP_003133769.1 NZ_CP020704:c5910594-5910289 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT75313 NZ_CP020704:c5910594-5910289 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCCCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References