75303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5818353..5818948 Replicon chromosome
Accession NZ_CP020703
Organism Pseudomonas aeruginosa strain PASGNDM345

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag B7W86_RS28095 Protein ID WP_003113526.1
Coordinates 5818670..5818948 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B7W86_RS28090 Protein ID WP_003133769.1
Coordinates 5818353..5818658 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7W86_RS28060 5813375..5813665 - 291 WP_031757220.1 DUF5447 family protein -
B7W86_RS28065 5813841..5814113 - 273 WP_004352675.1 hypothetical protein -
B7W86_RS28075 5814553..5814888 + 336 WP_023094905.1 hypothetical protein -
B7W86_RS33445 5814982..5815572 + 591 WP_071536478.1 SLATT domain-containing protein -
B7W86_RS28080 5815569..5816834 + 1266 WP_023094906.1 nucleotidyltransferase -
B7W86_RS28085 5816918..5817910 - 993 WP_003133766.1 hypothetical protein -
B7W86_RS28090 5818353..5818658 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
B7W86_RS28095 5818670..5818948 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7W86_RS28105 5819277..5821505 + 2229 WP_003133778.1 TonB-dependent receptor -
B7W86_RS28110 5821576..5822223 - 648 WP_003095021.1 carbonate dehydratase -
B7W86_RS28115 5822285..5823523 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T75303 WP_003113526.1 NZ_CP020703:c5818948-5818670 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T75303 NZ_CP020703:c5818948-5818670 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT75303 WP_003133769.1 NZ_CP020703:c5818658-5818353 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT75303 NZ_CP020703:c5818658-5818353 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCCCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References