Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2815983..2816410 Replicon chromosome
Accession NZ_CP020664
Organism Microcystis sp. MC19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B5D77_RS14255 Protein ID WP_081504695.1
Coordinates 2816282..2816410 (-) Length 43 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B5D77_RS14250 Protein ID WP_046662171.1
Coordinates 2815983..2816282 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5D77_RS14235 2811829..2812845 - 1017 WP_039900510.1 type I glyceraldehyde-3-phosphate dehydrogenase -
B5D77_RS14240 2813241..2814668 + 1428 WP_106909066.1 UDP-N-acetylmuramate--L-alanine ligase -
B5D77_RS14245 2814906..2815784 + 879 WP_106909067.1 UDP-N-acetylmuramate dehydrogenase -
B5D77_RS14250 2815983..2816282 - 300 WP_046662171.1 HigA family addiction module antidote protein Antitoxin
B5D77_RS14255 2816282..2816410 - 129 WP_081504695.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5D77_RS14260 2816846..2817238 - 393 WP_002791850.1 hypothetical protein -
B5D77_RS14265 2817235..2817612 - 378 WP_106909068.1 DUF433 domain-containing protein -
B5D77_RS14275 2818413..2819084 - 672 WP_016514528.1 hypothetical protein -
B5D77_RS14280 2819515..2819760 - 246 WP_106909069.1 DUF433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-42)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-82)


Sequences

Toxin        


Download         Length: 43 a.a.        Molecular weight: 4781.36 Da        Isoelectric Point: 5.4930

>T75285 WP_081504695.1 NZ_CP020664:c2816410-2816282 [Microcystis sp. MC19]
MVLHELAGQRKGTWTVRVSGNWRITFTFDGVGACDVDLEDYH

Download         Length: 129 bp

>T75285 NZ_CP020664:c2816410-2816282 [Microcystis sp. MC19]
TTGGTACTTCATGAACTGGCAGGGCAACGTAAAGGAACCTGGACGGTGAGAGTATCTGGAAACTGGCGGATCACTTTCAC
CTTTGACGGTGTTGGTGCTTGTGATGTCGATCTTGAGGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10910.65 Da        Isoelectric Point: 8.0442

>AT75285 WP_046662171.1 NZ_CP020664:c2816282-2815983 [Microcystis sp. MC19]
MKMHNPPHPGEVLKELCLEPLNLTVTEAAEALGVSRKTLSAILNGRAGISPEMAIRLGKAFDTSPESWLNQQMQYDLWQA
EQTIGNIKVKRLSVRSAIA

Download         Length: 300 bp

>AT75285 NZ_CP020664:c2816282-2815983 [Microcystis sp. MC19]
ATGAAAATGCATAATCCACCACATCCTGGTGAAGTTCTTAAAGAACTTTGTCTCGAACCTTTGAATCTGACTGTGACTGA
GGCTGCTGAAGCATTGGGTGTAAGTCGAAAAACCCTATCTGCCATCTTAAATGGTAGGGCAGGTATTAGCCCCGAAATGG
CAATTCGCTTAGGGAAAGCTTTCGATACATCTCCTGAAAGTTGGCTCAATCAGCAAATGCAATACGATCTATGGCAAGCA
GAGCAGACAATTGGCAATATCAAAGTCAAACGGCTATCAGTGCGATCAGCGATCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References