Detailed information of TA system TA075250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1508550..1509073
• Replicon: chromosome
• Accession: NZ_CP020656
• Organism: Staphylococcus aureus strain K5

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: B7R57_RS07910
• Protein ID: WP_000074043.1
• Coordinates: 1508550..1508816 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: B7R57_RS07915
• Protein ID: WP_000587618.1
• Coordinates: 1508816..1509073 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7R57_RS07890	1503856..1505043	-	1188	WP_000026194.1	MFS transporter	-
B7R57_RS07895	1505439..1506215	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
B7R57_RS07900	1506208..1506870	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
B7R57_RS07905	1507118..1508194	-	1077	WP_001076673.1	M42 family metallopeptidase	-
B7R57_RS07910	1508550..1508816	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
B7R57_RS07915	1508816..1509073	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B7R57_RS07925	1509433..1509888	+	456	WP_000732076.1	DUF1307 domain-containing protein	-
B7R57_RS07930	1510056..1511633	-	1578	WP_101766505.1	FMN-binding glutamate synthase family protein	-
B7R57_RS07935	1511828..1512577	+	750	WP_104930238.1	hypothetical protein	-
B7R57_RS07940	1512808..1514001	-	1194	WP_000675407.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T75250 WP_000074043.1 NZ_CP020656:c1508816-1508550 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T75250 NZ_CP020656:c1508816-1508550 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT75250 WP_000587618.1 NZ_CP020656:c1509073-1508816 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT75250 NZ_CP020656:c1509073-1508816 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2