Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1451722..1452239 Replicon chromosome
Accession NZ_CP020656
Organism Staphylococcus aureus strain K5

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag B7R57_RS07590 Protein ID WP_000113262.1
Coordinates 1451722..1451988 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag B7R57_RS07595 Protein ID WP_000584499.1
Coordinates 1451988..1452239 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7R57_RS07565 1447147..1447683 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
B7R57_RS07570 1447916..1448740 - 825 WP_000572040.1 formate/nitrite transporter family protein -
B7R57_RS07575 1448957..1449139 - 183 WP_000230294.1 hypothetical protein -
B7R57_RS07580 1449223..1449690 - 468 WP_101766510.1 SRPBCC domain-containing protein -
B7R57_RS07585 1449876..1451426 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
B7R57_RS07590 1451722..1451988 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
B7R57_RS07595 1451988..1452239 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B7R57_RS07600 1452404..1452505 - 102 WP_031774922.1 hypothetical protein -
B7R57_RS07605 1452512..1453111 - 600 WP_000162813.1 DsbA family protein -
B7R57_RS07610 1453130..1453492 - 363 WP_000819843.1 DUF4467 domain-containing protein -
B7R57_RS07615 1453747..1454997 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
B7R57_RS07620 1455094..1455825 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
B7R57_RS07625 1455822..1456541 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T75247 WP_000113262.1 NZ_CP020656:c1451988-1451722 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T75247 NZ_CP020656:c1451988-1451722 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT75247 WP_000584499.1 NZ_CP020656:c1452239-1451988 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT75247 NZ_CP020656:c1452239-1451988 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References