Detailed information of TA system TA075227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1487084..1487784
• Replicon: chromosome
• Accession: NZ_CP020651
• Organism: Bordetella bronchiseptica strain D755

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: B7P00_RS07025
• Protein ID: WP_003809515.1
• Coordinates: 1487084..1487380 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: B7P00_RS07030
• Protein ID: WP_003809516.1
• Coordinates: 1487383..1487784 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P00_RS07005	1483380..1483922	+	543	WP_003809508.1	MOSC domain-containing protein	-
B7P00_RS07010	1484098..1485162	+	1065	WP_033451323.1	fructose-bisphosphate aldolase class II	-
B7P00_RS07015	1485248..1485694	-	447	WP_033451920.1	GFA family protein	-
B7P00_RS07020	1485920..1486801	+	882	WP_033451921.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
B7P00_RS07025	1487084..1487380	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
B7P00_RS07030	1487383..1487784	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
B7P00_RS07035	1487804..1488040	+	237	WP_003809519.1	hypothetical protein	-
B7P00_RS07040	1488048..1488527	+	480	WP_003809523.1	disulfide bond formation protein B	-
B7P00_RS07045	1488675..1489190	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B7P00_RS07050	1489193..1490383	+	1191	WP_003809527.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B7P00_RS07055	1490403..1491440	+	1038	WP_033451923.1	threonylcarbamoyl-AMP synthase	-
B7P00_RS07060	1491577..1492605	+	1029	WP_033447398.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T75227 WP_003809515.1 NZ_CP020651:1487084-1487380 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T75227 NZ_CP020651:1487084-1487380 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTTCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT75227 WP_003809516.1 NZ_CP020651:1487383-1487784 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT75227 NZ_CP020651:1487383-1487784 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6