Detailed information of TA system TA075219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1480848..1481548
• Replicon: chromosome
• Accession: NZ_CP020649
• Organism: Bordetella bronchiseptica strain E010

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: B7P10_RS06990
• Protein ID: WP_003809515.1
• Coordinates: 1480848..1481144 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: B7P10_RS06995
• Protein ID: WP_003809516.1
• Coordinates: 1481147..1481548 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P10_RS06970	1477145..1477687	+	543	WP_015064289.1	MOSC domain-containing protein	-
B7P10_RS06975	1477863..1478927	+	1065	WP_015064288.1	fructose-bisphosphate aldolase class II	-
B7P10_RS06980	1479012..1479458	-	447	WP_015064287.1	GFA family protein	-
B7P10_RS06985	1479684..1480565	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
B7P10_RS06990	1480848..1481144	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
B7P10_RS06995	1481147..1481548	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
B7P10_RS07000	1481568..1481804	+	237	WP_003809519.1	hypothetical protein	-
B7P10_RS07005	1481812..1482291	+	480	WP_003809523.1	disulfide bond formation protein B	-
B7P10_RS07010	1482439..1482954	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B7P10_RS07015	1482957..1484147	+	1191	WP_003809527.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B7P10_RS07020	1484167..1485204	+	1038	WP_003809529.1	threonylcarbamoyl-AMP synthase	-
B7P10_RS07025	1485341..1486369	+	1029	WP_033447398.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T75219 WP_003809515.1 NZ_CP020649:1480848-1481144 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T75219 NZ_CP020649:1480848-1481144 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT75219 WP_003809516.1 NZ_CP020649:1481147-1481548 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT75219 NZ_CP020649:1481147-1481548 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6