Detailed information of TA system TA075204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1468570..1469225
• Replicon: chromosome
• Accession: NZ_CP020645
• Organism: Bordetella bronchiseptica strain I943

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: B7P02_RS06945
• Protein ID: WP_049806323.1
• Coordinates: 1468570..1468821 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: B7P02_RS06950
• Protein ID: WP_003809516.1
• Coordinates: 1468824..1469225 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7P02_RS06920	1463730..1464860	-	1131	WP_004568222.1	helix-turn-helix transcriptional regulator	-
B7P02_RS06925	1465095..1465637	+	543	WP_004568221.1	MOSC domain-containing protein	-
B7P02_RS06930	1465813..1466877	+	1065	WP_003819826.1	fructose-bisphosphate aldolase class II	-
B7P02_RS06935	1466962..1467408	-	447	WP_003819827.1	GFA family protein	-
B7P02_RS06940	1467634..1468515	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
B7P02_RS06945	1468570..1468821	+	252	WP_049806323.1	type II toxin-antitoxin system MqsR family toxin	Toxin
B7P02_RS06950	1468824..1469225	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
B7P02_RS06955	1469245..1469481	+	237	WP_003819834.1	hypothetical protein	-
B7P02_RS06960	1469489..1469968	+	480	WP_003819836.1	disulfide bond formation protein B	-
B7P02_RS06965	1470117..1470632	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B7P02_RS06970	1470635..1471825	+	1191	WP_015041223.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B7P02_RS06975	1471845..1472882	+	1038	WP_003819838.1	threonylcarbamoyl-AMP synthase	-
B7P02_RS06980	1473019..1474041	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8940.46 Da
• Isoelectric Point: 9.7242

>T75204 WP_049806323.1 NZ_CP020645:1468570-1468821 [Bordetella bronchiseptica]
IGGAATKKPGQKRRAGAAALGLDFSAMVETVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T75204 NZ_CP020645:1468570-1468821 [Bordetella bronchiseptica]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAACCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGGATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT75204 WP_003809516.1 NZ_CP020645:1468824-1469225 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT75204 NZ_CP020645:1468824-1469225 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6