75201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2556519..2556703 Replicon chromosome
Accession NZ_CP020619
Organism Staphylococcus aureus strain JE2

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag B7H15_RS13500 Protein ID WP_000482650.1
Coordinates 2556596..2556703 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2556519..2556579 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7H15_RS13470 2552049..2552216 - 168 WP_001790576.1 hypothetical protein -
B7H15_RS13480 2552447..2554180 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
B7H15_RS13485 2554205..2555968 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2556519..2556579 + 61 - - Antitoxin
B7H15_RS13500 2556596..2556703 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
B7H15_RS13505 2556837..2557223 - 387 WP_000779358.1 flippase GtxA -
B7H15_RS13510 2557491..2558633 + 1143 WP_001176863.1 glycerate kinase -
B7H15_RS13515 2558693..2559352 + 660 WP_000831298.1 membrane protein -
B7H15_RS13520 2559534..2560745 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
B7H15_RS13525 2560868..2561341 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T75201 WP_000482650.1 NZ_CP020619:c2556703-2556596 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T75201 NZ_CP020619:c2556703-2556596 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT75201 NZ_CP020619:2556519-2556579 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References