Detailed information of TA system TA075199

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2266464..2266681
• Replicon: chromosome
• Accession: NZ_CP020619
• Organism: Staphylococcus aureus strain JE2

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: B7H15_RS11920
• Protein ID: WP_001802298.1
• Coordinates: 2266577..2266681 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2266464..2266519 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7H15_RS11900	2262601..2263266	-	666	WP_001024094.1	SDR family oxidoreductase	-
B7H15_RS11905	2263418..2263738	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
B7H15_RS11910	2263740..2264720	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
B7H15_RS11915	2264986..2266077	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2266464..2266519	+	56	-	-	Antitoxin
B7H15_RS11920	2266577..2266681	-	105	WP_001802298.1	hypothetical protein	Toxin
B7H15_RS15375	2266842..2267325	-	484	Protein_2196	recombinase family protein	-
B7H15_RS11930	2267368..2268504	-	1137	WP_000115564.1	SAP domain-containing protein	-
B7H15_RS11935	2268793..2268885	+	93	WP_001790138.1	hypothetical protein	-
B7H15_RS11940	2269590..2270447	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
B7H15_RS11945	2270515..2271297	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T75199 WP_001802298.1 NZ_CP020619:c2266681-2266577 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T75199 NZ_CP020619:c2266681-2266577 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75199 NZ_CP020619:2266464-2266519 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin