Detailed information of TA system TA075192

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2091794..2092093
• Replicon: chromosome
• Accession: NZ_CP020619
• Organism: Staphylococcus aureus strain JE2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: B7H15_RS10890
• Protein ID: WP_011447039.1
• Coordinates: 2091917..2092093 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2091794..2091849 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7H15_RS10835	2087125..2087385	+	261	WP_001791826.1	hypothetical protein	-
B7H15_RS10840	2087438..2087788	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
B7H15_RS10845	2088473..2088922	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
B7H15_RS15305	2089017..2089352	-	336	Protein_1997	SH3 domain-containing protein	-
B7H15_RS10870	2090002..2090493	-	492	WP_000919350.1	staphylokinase	-
B7H15_RS10875	2090684..2091439	-	756	WP_000861038.1	CHAP domain-containing protein	-
B7H15_RS10880	2091451..2091705	-	255	WP_000611512.1	phage holin	-
B7H15_RS10885	2091757..2091864	+	108	WP_001791821.1	hypothetical protein	-
-	2091786..2091925	+	140	NuclAT_0	-	-
-	2091786..2091925	+	140	NuclAT_0	-	-
-	2091786..2091925	+	140	NuclAT_0	-	-
-	2091786..2091925	+	140	NuclAT_0	-	-
-	2091794..2091849	+	56	-	-	Antitoxin
B7H15_RS10890	2091917..2092093	-	177	WP_011447039.1	putative holin-like toxin	Toxin
B7H15_RS10895	2092243..2092539	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
B7H15_RS10900	2092597..2092884	-	288	WP_001040261.1	hypothetical protein	-
B7H15_RS10905	2092931..2093083	-	153	WP_001153681.1	hypothetical protein	-
B7H15_RS10910	2093073..2096858	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	2083622..2146406	62784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T75192 WP_011447039.1 NZ_CP020619:c2092093-2091917 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T75192 NZ_CP020619:c2092093-2091917 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT75192 NZ_CP020619:2091794-2091849 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin