Detailed information of TA system TA075157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 82905..83563
• Replicon: plasmid pJBA13_1
• Accession: NZ_CP020582
• Organism: Acinetobacter baumannii strain JBA13

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: B7L31_RS00475
• Protein ID: WP_000312250.1
• Coordinates: 82905..83264 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: B7L31_RS00480
• Protein ID: WP_001096429.1
• Coordinates: 83264..83563 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L31_RS00435	78228..78542	-	315	WP_000708715.1	hypothetical protein	-
B7L31_RS00445	79408..79743	-	336	WP_000653925.1	hypothetical protein	-
B7L31_RS00450	79795..80553	-	759	WP_001053128.1	hypothetical protein	-
B7L31_RS00455	80620..81003	-	384	WP_000654348.1	hypothetical protein	-
B7L31_RS00460	81142..81840	-	699	WP_000873188.1	hypothetical protein	-
B7L31_RS00465	81907..82089	-	183	WP_000373385.1	hypothetical protein	-
B7L31_RS00470	82138..82704	-	567	WP_000710385.1	hypothetical protein	-
B7L31_RS00475	82905..83264	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7L31_RS00480	83264..83563	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
B7L31_RS00490	84099..84635	-	537	WP_000732006.1	hypothetical protein	-
B7L31_RS00495	84685..85239	-	555	WP_000790082.1	hypothetical protein	-
B7L31_RS00505	85475..86203	-	729	WP_001022819.1	hypothetical protein	-
B7L31_RS00510	86240..86581	-	342	WP_002001471.1	hypothetical protein	-
B7L31_RS00515	86625..87137	-	513	WP_000840065.1	hypothetical protein	-
B7L31_RS00520	87219..87728	-	510	WP_001043200.1	hypothetical protein	-
B7L31_RS00525	87768..88397	-	630	WP_000701002.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..90972	90972

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T75157 WP_000312250.1 NZ_CP020582:82905-83264 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T75157 NZ_CP020582:82905-83264 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT75157 WP_001096429.1 NZ_CP020582:83264-83563 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT75157 NZ_CP020582:83264-83563 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA