Detailed information of TA system TA075149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 30299..30957
• Replicon: plasmid pSSA12_1
• Accession: NZ_CP020577
• Organism: Acinetobacter baumannii strain SSA12

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: B7L38_RS00260
• Protein ID: WP_000312250.1
• Coordinates: 30299..30658 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: B7L38_RS00265
• Protein ID: WP_001096429.1
• Coordinates: 30658..30957 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B7L38_RS00225	25805..26119	-	315	WP_000708714.1	hypothetical protein	-
B7L38_RS00235	27189..27947	-	759	WP_001053129.1	hypothetical protein	-
B7L38_RS00240	28014..28397	-	384	WP_000654349.1	hypothetical protein	-
B7L38_RS00245	28536..29234	-	699	WP_000873190.1	hypothetical protein	-
B7L38_RS00250	29301..29483	-	183	WP_000373385.1	hypothetical protein	-
B7L38_RS00255	29532..30098	-	567	WP_041171756.1	hypothetical protein	-
B7L38_RS00260	30299..30658	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B7L38_RS00265	30658..30957	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
B7L38_RS00270	31058..31321	+	264	WP_000110863.1	hypothetical protein	-
B7L38_RS00275	31414..31896	-	483	WP_001052677.1	hypothetical protein	-
B7L38_RS00285	32519..33055	-	537	WP_000731981.1	hypothetical protein	-
B7L38_RS00290	33105..33659	-	555	WP_000790085.1	hypothetical protein	-
B7L38_RS00295	33740..34249	-	510	WP_001043199.1	hypothetical protein	-
B7L38_RS00300	34289..34918	-	630	WP_002081923.1	hypothetical protein	-
B7L38_RS00305	34935..35114	-	180	WP_002081921.1	hypothetical protein	-
B7L38_RS00310	35090..35662	-	573	WP_000429351.1	hypothetical protein	-
B7L38_RS00315	35667..35924	-	258	WP_000834292.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..73264	73264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T75149 WP_000312250.1 NZ_CP020577:30299-30658 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T75149 NZ_CP020577:30299-30658 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT75149 WP_001096429.1 NZ_CP020577:30658-30957 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT75149 NZ_CP020577:30658-30957 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA