Detailed information of TA system TA075138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 952173..952675
• Replicon: chromosome
• Accession: NZ_CP020562
• Organism: Halomonas sp. GT

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: B6A39_RS04405
• Protein ID: WP_083001759.1
• Coordinates: 952412..952675 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: B6A39_RS04400
• Protein ID: WP_083001758.1
• Coordinates: 952173..952415 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A39_RS04380	948938..949636	-	699	WP_083001751.1	thiaminase II	-
B6A39_RS04385	950012..950161	-	150	WP_083001752.1	phage integrase N-terminal SAM-like domain-containing protein	-
B6A39_RS04390	950399..950848	+	450	WP_083001754.1	hypothetical protein	-
B6A39_RS04395	951120..952025	+	906	WP_083001756.1	hypothetical protein	-
B6A39_RS04400	952173..952415	+	243	WP_083001758.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B6A39_RS04405	952412..952675	+	264	WP_083001759.1	Txe/YoeB family addiction module toxin	Toxin
B6A39_RS04410	952813..953634	-	822	WP_083001761.1	aldo/keto reductase	-
B6A39_RS04415	953923..955575	-	1653	WP_083001763.1	sodium:solute symporter family protein	-
B6A39_RS04420	956048..956836	-	789	WP_083001765.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10065.77 Da
• Isoelectric Point: 10.0969

>T75138 WP_083001759.1 NZ_CP020562:952412-952675 [Halomonas sp. GT]
VTWTLVYTKQAQKDAKKLASSGLKPKAQELLALIAEDPYRKPPPFEKLIGDLAGAYSRRINIQHRLVYQVLEDERVVKVL
RLWSLYE

Nucleotide

• Length: 264 bp

>T75138 NZ_CP020562:952412-952675 [Halomonas sp. GT]
GTGACATGGACGTTGGTTTACACCAAACAAGCCCAGAAGGACGCAAAGAAGCTGGCTTCAAGCGGCCTCAAGCCAAAAGC
CCAAGAGTTGTTGGCCCTAATTGCAGAAGATCCGTACCGCAAACCGCCCCCGTTTGAGAAGCTCATAGGTGATCTTGCGG
GCGCCTATTCACGCCGCATTAATATTCAGCATCGTTTGGTCTACCAAGTGCTTGAGGACGAGCGAGTGGTGAAAGTCCTC
AGGCTATGGAGCCTCTACGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9033.11 Da
• Isoelectric Point: 4.0533

>AT75138 WP_083001758.1 NZ_CP020562:952173-952415 [Halomonas sp. GT]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNKAVLVSEEDWSAIQETLYLLSVPSMRESIREGMDTSVDECDGELDW

Nucleotide

• Length: 243 bp

>AT75138 NZ_CP020562:952173-952415 [Halomonas sp. GT]
ATGACCGGCATCACAGCAACGGAGGCGCGGAGCAACCTTTATCGGTTGATTGACGAGACCGCCGAGTCCCACCAACCCAT
CGTCATCATGGGTAAGCGGAACAAAGCCGTCCTGGTTTCCGAGGAAGACTGGTCCGCCATTCAGGAAACGCTTTACCTGC
TCTCCGTACCGAGTATGCGGGAGTCTATTCGTGAGGGAATGGATACCTCCGTGGATGAATGCGATGGGGAGCTGGACTGG
TGA