Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1183761..1184383 Replicon chromosome
Accession NZ_CP020560
Organism Pseudomonas aeruginosa strain CR1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B7D75_RS05710 Protein ID WP_023910260.1
Coordinates 1183761..1184075 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B7D75_RS05715 Protein ID WP_023910258.1
Coordinates 1184078..1184383 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D75_RS05680 1179425..1180426 + 1002 WP_079753611.1 site-specific integrase -
B7D75_RS05685 1180495..1180806 + 312 WP_031631670.1 outer membrane protein assembly factor BamE -
B7D75_RS05690 1180938..1181588 + 651 WP_058172679.1 BRCT domain-containing protein -
B7D75_RS05695 1181686..1182159 + 474 WP_124103543.1 hypothetical protein -
B7D75_RS05700 1182447..1183190 + 744 WP_058172667.1 DUF3800 domain-containing protein -
B7D75_RS05710 1183761..1184075 + 315 WP_023910260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B7D75_RS05715 1184078..1184383 + 306 WP_023910258.1 helix-turn-helix domain-containing protein Antitoxin
B7D75_RS05720 1184444..1184743 - 300 WP_058172668.1 hypothetical protein -
B7D75_RS05725 1184844..1185056 - 213 WP_033967225.1 hypothetical protein -
B7D75_RS05730 1185053..1186933 - 1881 WP_107113824.1 DNA cytosine methyltransferase -
B7D75_RS29520 1186930..1187082 - 153 WP_169433150.1 hypothetical protein -
B7D75_RS05740 1187091..1187825 - 735 WP_033971084.1 hypothetical protein -
B7D75_RS05745 1187892..1188701 - 810 WP_028680747.1 DUF2303 family protein -
B7D75_RS05750 1188747..1189094 - 348 WP_031632202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1173875..1220846 46971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11776.54 Da        Isoelectric Point: 9.4385

>T75131 WP_023910260.1 NZ_CP020560:1183761-1184075 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR

Download         Length: 315 bp

>T75131 NZ_CP020560:1183761-1184075 [Pseudomonas aeruginosa]
ATGATCTTCATCGAAACGCCAGTCTTCACGAAGCGGATTCTCGCGCTGGTAGACGACGAGACCTATCGCAAGCTTCAAGA
AGACCTAACGCTCCACCCGGACGCCGGAGTGGTCATTGAAGGCACGGGTGGCGTGCGCAAGATTCGCATTGCTGCCAATG
GCCACGGGAAAAGAGGCGGCGCCCGGGTCATCTACTACCATTTCACATCCGCCTCTCAAATTGCATTCCTGCTGGCCTAT
GACAAAGCATCGCAGGAAGATCTGACTGCCGATCAGAAAAAGATGCTTCGGCAGATCGTTGAGAACTGGAGATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11316.84 Da        Isoelectric Point: 7.2077

>AT75131 WP_023910258.1 NZ_CP020560:1184078-1184383 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES

Download         Length: 306 bp

>AT75131 NZ_CP020560:1184078-1184383 [Pseudomonas aeruginosa]
ATGGACAAAGAACTCTTCGCTGAACTGGTCGAAAGCGTGACCCAGATGGACGAGATCGTGCGTGGCGAACGTCAACCTTC
CCGCGAGTTCCACGTCGACGCGGTGAAGGTCAAGGAAATCCGCCGCGCTACTGGCCTGTCCCAGGCCAAATTCGCCCGAA
AGATCGATGTTGCTGTTGGAACCCTGCGCAATTGGGAGCAAGGGCGCCGCGATCCCGAGGGGCCTGCCCGCGCCCTGCTC
CGGGCCATTGACAATGATCCGGTTCATGTTCTGGCTGCCCTGAATGGTGGCCCGCGAGAAAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References