Detailed information of TA system TA075113

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4954254..4954666
• Replicon: chromosome
• Accession: NZ_CP020545
• Organism: Escherichia coli strain ZJ3920

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: B6V57_RS25805
• Protein ID: WP_001622590.1
• Coordinates: 4954254..4954595 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4954590..4954666 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6V57_RS25795	4951667..4952713	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
B6V57_RS25800	4952713..4954092	-	1380	WP_032147538.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
B6V57_RS25805	4954254..4954595	-	342	WP_001622590.1	endoribonuclease SymE	Toxin
-	4954590..4954666	+	77	NuclAT_5	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_5	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_5	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_5	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_6	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_6	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_6	-	Antitoxin
-	4954590..4954666	+	77	NuclAT_6	-	Antitoxin
B6V57_RS25810	4954823..4956217	-	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
B6V57_RS25815	4956214..4957803	-	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4941963..4956217	14254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12144.98 Da
• Isoelectric Point: 9.1114

>T75113 WP_001622590.1 NZ_CP020545:c4954595-4954254 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPGYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T75113 NZ_CP020545:c4954595-4954254 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGGTTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT75113 NZ_CP020545:4954590-4954666 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCAGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin