75097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2066457..2066959 Replicon chromosome
Accession NZ_CP020545
Organism Escherichia coli strain ZJ3920

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0H2Z0A6
Locus tag B6V57_RS10945 Protein ID WP_000767826.1
Coordinates 2066457..2066711 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag B6V57_RS10950 Protein ID WP_001259255.1
Coordinates 2066708..2066959 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6V57_RS10915 2061472..2061699 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
B6V57_RS10920 2061713..2062771 - 1059 WP_000492334.1 transport protein YeeE -
B6V57_RS10925 2062950..2064308 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
B6V57_RS10930 2064298..2064360 - 63 WP_010723108.1 membrane protein YoeI -
B6V57_RS10935 2064575..2065504 - 930 WP_000803363.1 LysR family transcriptional regulator -
B6V57_RS10940 2065550..2066374 - 825 WP_000754737.1 SDR family oxidoreductase -
B6V57_RS10945 2066457..2066711 - 255 WP_000767826.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
B6V57_RS10950 2066708..2066959 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
B6V57_RS10955 2067242..2067283 + 42 WP_010989201.1 his operon leader peptide -
B6V57_RS10960 2067429..2068328 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
B6V57_RS10965 2068334..2069638 + 1305 WP_001350692.1 histidinol dehydrogenase -
B6V57_RS10970 2069635..2070705 + 1071 WP_000108997.1 histidinol-phosphate transaminase -
B6V57_RS10975 2070705..2071772 + 1068 WP_000080128.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T75097 WP_000767826.1 NZ_CP020545:c2066711-2066457 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRIIEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T75097 NZ_CP020545:c2066711-2066457 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT75097 WP_001259255.1 NZ_CP020545:c2066959-2066708 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT75097 NZ_CP020545:c2066959-2066708 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z0A6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References