Detailed information of TA system TA075030

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2248547..2248772
• Replicon: chromosome
• Accession: NZ_CP020528
• Organism: Enterobacter cloacae strain 174

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A8S7B7V6
• Locus tag: AXJ76_RS11475
• Protein ID: WP_000813256.1
• Coordinates: 2248617..2248772 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2248547..2248605 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXJ76_RS11440	2243959..2244378	-	420	WP_000362155.1	hypothetical protein	-
AXJ76_RS11445	2244479..2244760	+	282	WP_000391950.1	helix-turn-helix domain-containing protein	-
AXJ76_RS11450	2244744..2245169	+	426	WP_000693832.1	hypothetical protein	-
AXJ76_RS11455	2245241..2246311	+	1071	WP_021536266.1	hypothetical protein	-
AXJ76_RS11460	2246352..2246777	+	426	WP_001151208.1	DUF977 family protein	-
AXJ76_RS11465	2247005..2248030	+	1026	WP_000379313.1	hypothetical protein	-
-	2248547..2248605	-	59	-	-	Antitoxin
AXJ76_RS11475	2248617..2248772	+	156	WP_000813256.1	type I toxin-antitoxin system toxin HokD	Toxin
AXJ76_RS11480	2249231..2249509	+	279	WP_086532009.1	hypothetical protein	-
AXJ76_RS11485	2249511..2250560	+	1050	WP_001265033.1	DUF968 domain-containing protein	-
AXJ76_RS11490	2250573..2250947	+	375	WP_021536265.1	RusA family crossover junction endodeoxyribonuclease	-
AXJ76_RS11495	2250944..2251765	+	822	WP_045350650.1	antitermination protein	-
AXJ76_RS11515	2252661..2252792	+	132	WP_000562553.1	DUF3927 family protein	-
AXJ76_RS11525	2253159..2253587	+	429	WP_000506933.1	cell envelope integrity protein TolA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2237895..2274069	36174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5764.94 Da
• Isoelectric Point: 6.1531

>T75030 WP_000813256.1 NZ_CP020528:2248617-2248772 [Enterobacter cloacae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTVYEPEE

Nucleotide

• Length: 156 bp

>T75030 NZ_CP020528:2248617-2248772 [Enterobacter cloacae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGTCTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT75030 NZ_CP020528:c2248605-2248547 [Enterobacter cloacae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin