74993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1831604..1832106 Replicon chromosome
Accession NZ_CP020520
Organism Escherichia coli strain 190

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag A9X72_RS09310 Protein ID WP_000767829.1
Coordinates 1831852..1832106 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag A9X72_RS09305 Protein ID WP_001259255.1
Coordinates 1831604..1831855 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9X72_RS09275 1826782..1827849 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
A9X72_RS09280 1827849..1828919 - 1071 WP_001362957.1 histidinol-phosphate transaminase -
A9X72_RS09285 1828916..1830220 - 1305 WP_001774536.1 histidinol dehydrogenase -
A9X72_RS09290 1830226..1831125 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
A9X72_RS09300 1831271..1831321 - 51 WP_001364200.1 his operon leader peptide -
A9X72_RS09305 1831604..1831855 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
A9X72_RS09310 1831852..1832106 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
A9X72_RS09315 1832189..1833013 + 825 WP_000754758.1 SDR family oxidoreductase -
A9X72_RS09320 1833059..1833988 + 930 WP_000803351.1 LysR family transcriptional regulator -
A9X72_RS09325 1834203..1834265 + 63 WP_010723108.1 membrane protein YoeI -
A9X72_RS09330 1834255..1835613 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
A9X72_RS09335 1835792..1836850 + 1059 WP_000492315.1 transport protein YeeE -
A9X72_RS09340 1836864..1837091 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T74993 WP_000767829.1 NZ_CP020520:1831852-1832106 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T74993 NZ_CP020520:1831852-1832106 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT74993 WP_001259255.1 NZ_CP020520:1831604-1831855 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT74993 NZ_CP020520:1831604-1831855 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References