Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2235877..2236098 Replicon chromosome
Accession NZ_CP020516
Organism Escherichia coli strain 222

Toxin (Protein)


Gene name ldrD Uniprot ID A0A229AEQ8
Locus tag A9P13_RS11615 Protein ID WP_000176713.1
Coordinates 2235877..2235984 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2236032..2236098 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P13_RS11580 2231011..2232093 + 1083 WP_000804726.1 peptide chain release factor 1 -
A9P13_RS11585 2232093..2232926 + 834 WP_000456570.1 peptide chain release factor N(5)-glutamine methyltransferase -
A9P13_RS11590 2232923..2233315 + 393 WP_000200377.1 invasion regulator SirB2 -
A9P13_RS11595 2233319..2234128 + 810 WP_001257044.1 invasion regulator SirB1 -
A9P13_RS11600 2234164..2235018 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
A9P13_RS11610 2235213..2235671 + 459 WP_000526135.1 IS200/IS605 family transposase -
A9P13_RS11615 2235877..2235984 - 108 WP_000176713.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2236032..2236098 + 67 NuclAT_21 - Antitoxin
- 2236032..2236098 + 67 NuclAT_21 - Antitoxin
- 2236032..2236098 + 67 NuclAT_21 - Antitoxin
- 2236032..2236098 + 67 NuclAT_21 - Antitoxin
- 2236032..2236098 + 67 NuclAT_26 - Antitoxin
- 2236032..2236098 + 67 NuclAT_26 - Antitoxin
- 2236032..2236098 + 67 NuclAT_26 - Antitoxin
- 2236032..2236098 + 67 NuclAT_26 - Antitoxin
- 2236032..2236098 + 67 NuclAT_31 - Antitoxin
- 2236032..2236098 + 67 NuclAT_31 - Antitoxin
- 2236032..2236098 + 67 NuclAT_31 - Antitoxin
- 2236032..2236098 + 67 NuclAT_31 - Antitoxin
- 2236032..2236098 + 67 NuclAT_36 - Antitoxin
- 2236032..2236098 + 67 NuclAT_36 - Antitoxin
- 2236032..2236098 + 67 NuclAT_36 - Antitoxin
- 2236032..2236098 + 67 NuclAT_36 - Antitoxin
- 2236032..2236098 + 67 NuclAT_38 - Antitoxin
- 2236032..2236098 + 67 NuclAT_38 - Antitoxin
- 2236032..2236098 + 67 NuclAT_38 - Antitoxin
- 2236032..2236098 + 67 NuclAT_38 - Antitoxin
- 2236032..2236098 + 67 NuclAT_43 - Antitoxin
- 2236032..2236098 + 67 NuclAT_43 - Antitoxin
- 2236032..2236098 + 67 NuclAT_43 - Antitoxin
- 2236032..2236098 + 67 NuclAT_43 - Antitoxin
- 2236034..2236097 + 64 NuclAT_46 - -
- 2236034..2236097 + 64 NuclAT_46 - -
- 2236034..2236097 + 64 NuclAT_46 - -
- 2236034..2236097 + 64 NuclAT_46 - -
- 2236034..2236097 + 64 NuclAT_48 - -
- 2236034..2236097 + 64 NuclAT_48 - -
- 2236034..2236097 + 64 NuclAT_48 - -
- 2236034..2236097 + 64 NuclAT_48 - -
A9P13_RS11620 2236412..2236519 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 2236572..2236633 + 62 NuclAT_45 - -
- 2236572..2236633 + 62 NuclAT_45 - -
- 2236572..2236633 + 62 NuclAT_45 - -
- 2236572..2236633 + 62 NuclAT_45 - -
- 2236572..2236633 + 62 NuclAT_47 - -
- 2236572..2236633 + 62 NuclAT_47 - -
- 2236572..2236633 + 62 NuclAT_47 - -
- 2236572..2236633 + 62 NuclAT_47 - -
- 2236572..2236634 + 63 NuclAT_22 - -
- 2236572..2236634 + 63 NuclAT_22 - -
- 2236572..2236634 + 63 NuclAT_22 - -
- 2236572..2236634 + 63 NuclAT_22 - -
- 2236572..2236634 + 63 NuclAT_27 - -
- 2236572..2236634 + 63 NuclAT_27 - -
- 2236572..2236634 + 63 NuclAT_27 - -
- 2236572..2236634 + 63 NuclAT_27 - -
- 2236572..2236634 + 63 NuclAT_32 - -
- 2236572..2236634 + 63 NuclAT_32 - -
- 2236572..2236634 + 63 NuclAT_32 - -
- 2236572..2236634 + 63 NuclAT_32 - -
- 2236572..2236634 + 63 NuclAT_37 - -
- 2236572..2236634 + 63 NuclAT_37 - -
- 2236572..2236634 + 63 NuclAT_37 - -
- 2236572..2236634 + 63 NuclAT_37 - -
- 2236572..2236634 + 63 NuclAT_39 - -
- 2236572..2236634 + 63 NuclAT_39 - -
- 2236572..2236634 + 63 NuclAT_39 - -
- 2236572..2236634 + 63 NuclAT_39 - -
- 2236572..2236634 + 63 NuclAT_44 - -
- 2236572..2236634 + 63 NuclAT_44 - -
- 2236572..2236634 + 63 NuclAT_44 - -
- 2236572..2236634 + 63 NuclAT_44 - -
A9P13_RS11630 2236925..2238025 - 1101 WP_001309461.1 sodium-potassium/proton antiporter ChaA -
A9P13_RS11635 2238295..2238525 + 231 WP_001146444.1 putative cation transport regulator ChaB -
A9P13_RS11640 2238683..2239378 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
A9P13_RS11645 2239422..2239775 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2235213..2235671 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4031.79 Da        Isoelectric Point: 11.4779

>T74941 WP_000176713.1 NZ_CP020516:c2235984-2235877 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T74941 NZ_CP020516:c2235984-2235877 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT74941 NZ_CP020516:2236032-2236098 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229AEQ8

Antitoxin

Download structure file

References