Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 40910..41567 | Replicon | plasmid unnamed4 |
| Accession | NZ_CP020513 | ||
| Organism | Escherichia coli strain 165 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | AWB10_RS28515 | Protein ID | WP_000270043.1 |
| Coordinates | 41217..41567 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AWB10_RS28510 | Protein ID | WP_000124640.1 |
| Coordinates | 40910..41212 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AWB10_RS28460 | 36535..36963 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| AWB10_RS28465 | 37020..37379 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| AWB10_RS28470 | 37379..37825 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| AWB10_RS28475 | 37822..38340 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| AWB10_RS28480 | 38340..38570 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| AWB10_RS28485 | 38557..39414 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| AWB10_RS28495 | 39645..40172 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| AWB10_RS28500 | 40230..40502 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| AWB10_RS28505 | 40590..40883 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| AWB10_RS28510 | 40910..41212 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| AWB10_RS28515 | 41217..41567 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AWB10_RS28520 | 41730..42278 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| AWB10_RS28530 | 42619..42813 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| AWB10_RS28535 | 42824..43195 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| AWB10_RS28540 | 43188..43658 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| AWB10_RS28545 | 43673..44008 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| AWB10_RS28550 | 44105..44593 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| AWB10_RS28555 | 44596..45093 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| AWB10_RS28560 | 45308..46012 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..46056 | 46056 | |
| - | flank | IS/Tn | - | - | 45308..46012 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T74898 WP_000270043.1 NZ_CP020513:c41567-41217 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T74898 NZ_CP020513:c41567-41217 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT74898 WP_000124640.1 NZ_CP020513:c41212-40910 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT74898 NZ_CP020513:c41212-40910 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|