Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 65627..65897 | Replicon | plasmid unnamed1 |
Accession | NZ_CP020510 | ||
Organism | Escherichia coli strain 165 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | AWB10_RS27035 | Protein ID | WP_034169443.1 |
Coordinates | 65739..65897 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 65627..65690 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AWB10_RS28835 | 60655..60924 | + | 270 | WP_074015062.1 | hypothetical protein | - |
AWB10_RS29090 | 61165..61371 | + | 207 | WP_000547971.1 | hypothetical protein | - |
AWB10_RS27010 | 61397..61936 | + | 540 | WP_009426937.1 | single-stranded DNA-binding protein | - |
AWB10_RS27015 | 61998..62231 | + | 234 | WP_000006030.1 | DUF905 family protein | - |
AWB10_RS27020 | 62296..64254 | + | 1959 | WP_072652246.1 | ParB/RepB/Spo0J family partition protein | - |
AWB10_RS27025 | 64309..64743 | + | 435 | WP_032217500.1 | conjugation system SOS inhibitor PsiB | - |
AWB10_RS27030 | 64740..65459 | + | 720 | WP_050858785.1 | plasmid SOS inhibition protein A | - |
AWB10_RS28840 | 65471..65659 | - | 189 | WP_001299721.1 | hypothetical protein | - |
- | 65471..65695 | + | 225 | NuclAT_0 | - | - |
- | 65471..65695 | + | 225 | NuclAT_0 | - | - |
- | 65471..65695 | + | 225 | NuclAT_0 | - | - |
- | 65471..65695 | + | 225 | NuclAT_0 | - | - |
- | 65627..65690 | - | 64 | - | - | Antitoxin |
AWB10_RS27035 | 65739..65897 | + | 159 | WP_034169443.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
AWB10_RS29095 | 66588..66794 | + | 207 | WP_000547971.1 | hypothetical protein | - |
AWB10_RS27055 | 66819..67106 | + | 288 | WP_000107535.1 | hypothetical protein | - |
AWB10_RS27060 | 67224..68045 | + | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
AWB10_RS27065 | 68342..68989 | - | 648 | WP_000614935.1 | transglycosylase SLT domain-containing protein | - |
AWB10_RS27070 | 69266..69649 | + | 384 | WP_000124981.1 | relaxosome protein TraM | - |
AWB10_RS27075 | 69840..70526 | + | 687 | WP_001825184.1 | PAS domain-containing protein | - |
AWB10_RS27080 | 70620..70847 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId / rmtB / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr / tet(A) | - | 1..118182 | 118182 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T74890 WP_034169443.1 NZ_CP020510:65739-65897 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCELRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCELRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T74890 NZ_CP020510:65739-65897 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGCTTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGCTTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 64 bp
>AT74890 NZ_CP020510:c65690-65627 [Escherichia coli]
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|