Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1560..1800 Replicon plasmid unnamed1
Accession NZ_CP020496
Organism Escherichia coli strain 103

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag CPA47_RS25515 Protein ID WP_001312861.1
Coordinates 1560..1718 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 1762..1800 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPA47_RS25515 1560..1718 - 159 WP_001312861.1 type I toxin-antitoxin system Hok family toxin Toxin
- 1762..1800 - 39 NuclAT_1 - Antitoxin
- 1762..1800 - 39 NuclAT_1 - Antitoxin
- 1762..1800 - 39 NuclAT_1 - Antitoxin
- 1762..1800 - 39 NuclAT_1 - Antitoxin
- 3240..3342 - 103 NuclAT_0 - -
- 3240..3342 - 103 NuclAT_0 - -
- 3240..3342 - 103 NuclAT_0 - -
- 3240..3342 - 103 NuclAT_0 - -
CPA47_RS25525 3354..4073 - 720 WP_001276232.1 plasmid SOS inhibition protein A -
CPA47_RS25530 4070..4504 - 435 WP_000845940.1 conjugation system SOS inhibitor PsiB -
CPA47_RS25535 4559..6517 - 1959 WP_000117179.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / dfrA17 / aadA5 / qacE / sul1 / blaTEM-1B / blaCTX-M-15 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IId - 1..120668 120668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T74786 WP_001312861.1 NZ_CP020496:c1718-1560 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T74786 NZ_CP020496:c1718-1560 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGAGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 39 bp

>AT74786 NZ_CP020496:c1800-1762 [Escherichia coli]
CATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB P11895

Antitoxin

Download structure file

References