Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 80815..81350 Replicon plasmid unnamed1
Accession NZ_CP020489
Organism Enterococcus faecium strain CFSAN059071

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag B6S06_RS15295 Protein ID WP_002314366.1
Coordinates 80815..81087 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag B6S06_RS15300 Protein ID WP_002297422.1
Coordinates 81087..81350 (-) Length 88 a.a.

Genomic Context

B6S06_RS15265B6S06_RS15270B6S06_RS15305B6S06_RS15250B6S06_RS16550B6S06_RS15275B6S06_RS15280B6S06_RS15285B6S06_RS15290B6S06_RS15295B6S06_RS15300B6S06_RS15310B6S06_RS15315
Location: 77343..77986 (644 bp)
Type: Others
Protein ID: Protein_78
Location: 78062..78742 (681 bp)
Type: Others
Protein ID: WP_002331383.1
Location: 81584..82492 (909 bp)
Type: Others
Protein ID: Protein_86
Location: 75921..76370 (450 bp)
Type: Others
Protein ID: WP_010729386.1
Location: 76526..77068 (543 bp)
Type: Others
Protein ID: WP_002298088.1
Location: 78801..78989 (189 bp)
Type: Others
Protein ID: Protein_80
Location: 78990..79847 (858 bp)
Type: Others
Protein ID: WP_002292680.1
Location: 80133..80419 (287 bp)
Type: Others
Protein ID: Protein_82
Location: 80409..80738 (330 bp)
Type: Others
Protein ID: WP_002292678.1
Location: 80815..81087 (273 bp)
Type: Toxin
Protein ID: WP_002314366.1
Location: 81087..81350 (264 bp)
Type: Antitoxin
Protein ID: WP_002297422.1
Location: 82495..83670 (1176 bp)
Type: Others
Protein ID: WP_002336205.1
Location: 83673..85922 (2250 bp)
Type: Others
Protein ID: WP_002314387.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B6S06_RS1525075921..76370-450WP_010729386.1TlpA family protein disulfide reductase-
B6S06_RS1655076526..77068-543WP_002298088.1hypothetical protein-
B6S06_RS1526577343..77986+644Protein_78transposase-
B6S06_RS1527078062..78742+681WP_002331383.1IS6-like element IS1216 family transposase-
B6S06_RS1527578801..78989-189Protein_80hypothetical protein-
B6S06_RS1528078990..79847-858WP_002292680.1AAA family ATPase-
B6S06_RS1528580133..80419-287Protein_82type II toxin-antitoxin system RelE/ParE family toxin-
B6S06_RS1529080409..80738-330WP_002292678.1AbrB family transcriptional regulator-
B6S06_RS1529580815..81087-273WP_002314366.1Txe/YoeB family addiction module toxinToxin
B6S06_RS1530081087..81350-264WP_002297422.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
B6S06_RS1530581584..82492+909Protein_86IS982 family transposase-
B6S06_RS1531082495..83670-1176WP_002336205.1MFS transporter-
B6S06_RS1531583673..85922-2250WP_002314387.1alpha-galactosidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..217014217014
-insideIScluster/Tn--69252..9384224590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T74745 WP_002314366.1 NZ_CP020489:c81087-80815 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T74745 NZ_CP020489:c81087-80815 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT74745 WP_002297422.1 NZ_CP020489:c81350-81087 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT74745 NZ_CP020489:c81350-81087 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829F704

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829F006

References