Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1187908..1188431 Replicon chromosome
Accession NZ_CP020474
Organism Roseovarius mucosus strain SMR3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ROSMUCSMR3_RS05805 Protein ID WP_081506724.1
Coordinates 1188156..1188431 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ROSMUCSMR3_RS05800 Protein ID WP_081506723.1
Coordinates 1187908..1188159 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ROSMUCSMR3_RS05785 1183559..1184875 + 1317 WP_081506722.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
ROSMUCSMR3_RS05790 1185114..1186292 - 1179 WP_008281741.1 IS5-like element ISRssp10 family transposase -
ROSMUCSMR3_RS05795 1186376..1187656 - 1281 WP_008280670.1 DUF3422 domain-containing protein -
ROSMUCSMR3_RS05800 1187908..1188159 + 252 WP_081506723.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ROSMUCSMR3_RS05805 1188156..1188431 + 276 WP_081506724.1 Txe/YoeB family addiction module toxin Toxin
ROSMUCSMR3_RS05810 1188485..1189918 - 1434 WP_081506725.1 NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta -
ROSMUCSMR3_RS05815 1189932..1191506 - 1575 WP_081506726.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha -
ROSMUCSMR3_RS05820 1191634..1192068 - 435 WP_081506727.1 isoprenylcysteine carboxylmethyltransferase family protein -
ROSMUCSMR3_RS05825 1192163..1192915 + 753 WP_081508559.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1185114..1186292 1178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10677.09 Da        Isoelectric Point: 9.9477

>T74732 WP_081506724.1 NZ_CP020474:1188156-1188431 [Roseovarius mucosus]
VRLVFSDDAWEDFLWWQSTGRDKGLNRVIDLINATKRLPFKGIGKPESLKGDLTGWWSRRITDEHRLVYRVSVSGKGESQ
QLDIAQLRYHY

Download         Length: 276 bp

>T74732 NZ_CP020474:1188156-1188431 [Roseovarius mucosus]
GTGAGGTTGGTCTTTTCCGACGACGCTTGGGAAGATTTTCTCTGGTGGCAATCCACCGGGCGCGACAAGGGGCTGAACCG
GGTCATTGATCTGATCAACGCCACCAAGCGCCTGCCGTTCAAGGGCATCGGCAAGCCTGAATCGCTCAAAGGCGATCTCA
CCGGCTGGTGGTCACGGCGGATCACCGATGAACACCGCCTTGTCTACCGTGTCAGTGTCAGTGGCAAGGGCGAGAGCCAA
CAGCTCGACATTGCGCAGCTCAGATATCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9449.75 Da        Isoelectric Point: 6.7256

>AT74732 WP_081506723.1 NZ_CP020474:1187908-1188159 [Roseovarius mucosus]
MDVFTYTDARASLKEVMDRVIHDRTEVVVTRKNREAVVMISLEEYNAIQETLHLLKSPENARRLHRSIAQLTAGNGIARD
IDG

Download         Length: 252 bp

>AT74732 NZ_CP020474:1187908-1188159 [Roseovarius mucosus]
ATGGACGTGTTCACCTATACCGATGCCCGCGCCTCGCTCAAGGAGGTGATGGACCGCGTCATTCACGACCGCACAGAGGT
GGTCGTCACCCGCAAGAACCGCGAGGCGGTGGTGATGATCTCGCTCGAAGAATACAACGCCATTCAGGAAACCCTCCACC
TGCTCAAGAGCCCGGAAAACGCCCGCCGGCTGCACCGCTCGATTGCGCAACTGACCGCCGGGAATGGCATAGCGCGTGAC
ATTGACGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References