Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1857878..1858380 Replicon chromosome
Accession NZ_CP020468
Organism Actinomyces gaoshouyii strain pika_114

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag B6G06_RS07675 Protein ID WP_080462023.1
Coordinates 1858123..1858380 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag B6G06_RS07670 Protein ID WP_080462022.1
Coordinates 1857878..1858126 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6G06_RS07655 1853256..1855136 - 1881 WP_081171800.1 DUF2142 domain-containing protein -
B6G06_RS07660 1855133..1856563 - 1431 WP_081171801.1 bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase family protein/NAD(P)-dependent oxidoreductase -
B6G06_RS07665 1856784..1857701 + 918 WP_081171802.1 glycosyltransferase family 2 protein -
B6G06_RS07670 1857878..1858126 + 249 WP_080462022.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
B6G06_RS07675 1858123..1858380 + 258 WP_080462023.1 Txe/YoeB family addiction module toxin Toxin
B6G06_RS07680 1858462..1860525 - 2064 WP_205635449.1 glycoside hydrolase family 99-like domain-containing protein -
B6G06_RS07685 1860542..1861408 - 867 WP_080462025.1 glycosyltransferase -
B6G06_RS07690 1861405..1861644 - 240 WP_080462026.1 methyltransferase -
B6G06_RS07695 1861641..1862984 - 1344 WP_081172278.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9901.26 Da        Isoelectric Point: 9.5051

>T74728 WP_080462023.1 NZ_CP020468:1858123-1858380 [Actinomyces gaoshouyii]
VRISFTPKGWEDYTSWADTDRRMIPRINKLLDDAARHPFEGIGKPEPLRHALAGAWSRRITGEHRLVYIVDGDDIVVVQA
RYHYK

Download         Length: 258 bp

>T74728 NZ_CP020468:1858123-1858380 [Actinomyces gaoshouyii]
GTGAGGATCTCGTTCACGCCCAAGGGCTGGGAGGACTACACGTCCTGGGCGGACACCGATCGACGCATGATCCCGCGCAT
CAACAAGCTCCTCGACGATGCGGCCCGGCATCCCTTCGAAGGGATAGGCAAGCCGGAGCCGTTGCGTCACGCGCTGGCCG
GGGCCTGGTCGCGACGCATCACCGGCGAGCACCGGCTGGTCTACATCGTCGACGGGGATGACATCGTCGTCGTCCAGGCC
CGCTACCACTACAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9012.08 Da        Isoelectric Point: 5.5457

>AT74728 WP_080462022.1 NZ_CP020468:1857878-1858126 [Actinomyces gaoshouyii]
MSVMTASQARANLFGLIERVNEDASHVEITSRRGDAVLISRDEFDALEETAHLMRSPANAAHLLASLAQARRGESAEHEL
LR

Download         Length: 249 bp

>AT74728 NZ_CP020468:1857878-1858126 [Actinomyces gaoshouyii]
ATGTCCGTCATGACGGCGAGCCAGGCACGCGCGAATCTGTTCGGCCTCATCGAGCGGGTCAACGAGGATGCCTCCCATGT
GGAGATCACCTCCCGGCGCGGAGACGCGGTACTCATCTCCCGCGATGAGTTCGATGCCCTGGAGGAGACGGCGCATCTGA
TGCGCTCGCCCGCCAACGCGGCACATCTACTCGCCAGCCTGGCGCAGGCCCGTCGGGGGGAGAGCGCCGAGCACGAGCTA
CTGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References