Detailed information of TA system TA074710

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1579208..1579787
• Replicon: chromosome
• Accession: NZ_CP020467
• Organism: Staphylococcus aureus strain CFSAN007896

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: AB477_RS07810
• Protein ID: WP_001025401.1
• Coordinates: 1579542..1579787 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1579208..1579573 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB477_RS07770	1575951..1576508	-	558	WP_000645048.1	DUF2815 family protein	-
AB477_RS07775	1576534..1577700	-	1167	WP_031834538.1	DUF2800 domain-containing protein	-
AB477_RS07780	1577697..1578059	-	363	WP_000985976.1	hypothetical protein	-
AB477_RS07785	1578074..1578397	-	324	WP_000174994.1	hypothetical protein	-
AB477_RS07790	1578476..1578637	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
AB477_RS07795	1578650..1578913	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
AB477_RS07800	1578938..1579153	-	216	WP_001097552.1	hypothetical protein	-
AB477_RS07805	1579208..1579573	+	366	WP_001128433.1	hypothetical protein	Antitoxin
AB477_RS07810	1579542..1579787	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
AB477_RS07815	1579816..1580592	-	777	WP_001148544.1	Rha family transcriptional regulator	-
AB477_RS07820	1580606..1580842	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
AB477_RS07825	1580994..1581308	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
AB477_RS07830	1581321..1581782	+	462	WP_000525004.1	hypothetical protein	-
AB477_RS07835	1581800..1582384	+	585	WP_000825948.1	hypothetical protein	-
AB477_RS07840	1582723..1583346	-	624	WP_001166482.1	hypothetical protein	-
AB477_RS07845	1583456..1584661	+	1206	WP_000264191.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1538106..1602311	64205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T74710 WP_001025401.1 NZ_CP020467:c1579787-1579542 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T74710 NZ_CP020467:c1579787-1579542 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT74710 NZ_CP020467:1579208-1579573 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin