Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4622260..4622831 Replicon chromosome
Accession NZ_CP020465
Organism Colwellia beringensis strain NB097-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B5D82_RS19570 Protein ID WP_081154159.1
Coordinates 4622553..4622831 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B5D82_RS19565 Protein ID WP_081154157.1
Coordinates 4622260..4622553 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5D82_RS19975 4618423..4618560 - 138 WP_157673944.1 hypothetical protein -
B5D82_RS19540 4618939..4619358 - 420 WP_081154148.1 hypothetical protein -
B5D82_RS19545 4619400..4619924 - 525 WP_081154150.1 AAA family ATPase -
B5D82_RS19550 4619981..4621138 - 1158 WP_081154152.1 acyltransferase -
B5D82_RS19555 4621273..4621731 - 459 WP_081154154.1 DUF3291 domain-containing protein -
B5D82_RS19565 4622260..4622553 - 294 WP_081154157.1 HigA family addiction module antidote protein Antitoxin
B5D82_RS19570 4622553..4622831 - 279 WP_081154159.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5D82_RS19575 4623020..4623259 + 240 WP_081154161.1 type II toxin-antitoxin system ParD family antitoxin -
B5D82_RS19580 4623259..4623552 + 294 WP_081154162.1 type II toxin-antitoxin system RelE/ParE family toxin -
B5D82_RS19585 4623659..4623955 - 297 WP_157673945.1 hypothetical protein -
B5D82_RS19590 4624079..4625173 - 1095 WP_081154165.1 hypothetical protein -
B5D82_RS19600 4625619..4625921 - 303 WP_081154169.1 hypothetical protein -
B5D82_RS19605 4626049..4626480 - 432 WP_081154171.1 DUF2513 domain-containing protein -
B5D82_RS19610 4626592..4626903 - 312 WP_081154173.1 hypothetical protein -
B5D82_RS19615 4627014..4627250 - 237 WP_081154174.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10691.28 Da        Isoelectric Point: 10.0980

>T74704 WP_081154159.1 NZ_CP020465:c4622831-4622553 [Colwellia beringensis]
MIKSFKHKGLKKYFQTGNISGIQAKHQRKLRMQLAAIDTAQEIDDINLPGFKLHPLKGNRDGIWSITVNGNWRITFEFID
GNAFILNYEEYH

Download         Length: 279 bp

>T74704 NZ_CP020465:c4622831-4622553 [Colwellia beringensis]
ATGATTAAATCTTTTAAACACAAAGGCCTCAAGAAGTACTTCCAAACTGGAAATATCTCAGGTATTCAGGCAAAGCATCA
ACGTAAATTACGTATGCAACTAGCCGCAATAGATACCGCTCAAGAAATTGATGATATCAATTTGCCCGGTTTTAAATTAC
ATCCTTTAAAAGGTAATAGAGATGGGATTTGGTCTATAACTGTAAACGGTAACTGGCGCATTACTTTCGAGTTTATCGAT
GGCAATGCTTTCATTCTAAACTATGAGGAATATCACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.51 Da        Isoelectric Point: 7.3556

>AT74704 WP_081154157.1 NZ_CP020465:c4622553-4622260 [Colwellia beringensis]
MTMHNPPHPGEFIYDVYLEPAGFSCRYLAKQLDVASSTLNRVLKGQSAISPEMALRLSKAIGRTPESWLSMQDNYDLWHA
KQQINLTNVHSVNFAVV

Download         Length: 294 bp

>AT74704 NZ_CP020465:c4622553-4622260 [Colwellia beringensis]
ATGACTATGCATAATCCACCGCACCCAGGGGAGTTCATTTACGATGTTTATTTGGAGCCTGCTGGTTTTAGCTGTCGCTA
TCTGGCTAAACAATTAGATGTAGCATCATCTACTTTAAATCGAGTTCTTAAAGGTCAAAGTGCCATCTCTCCCGAAATGG
CACTGCGCTTGTCTAAAGCAATAGGAAGAACTCCTGAGAGTTGGTTATCAATGCAAGATAATTATGATCTTTGGCATGCT
AAGCAACAAATAAACTTAACCAATGTCCACTCAGTAAATTTTGCAGTGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References