Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 2579604..2580147 Replicon chromosome
Accession NZ_CP020464
Organism Lacticaseibacillus rhamnosus strain Pen

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag BVH57_RS13000 Protein ID WP_005709630.1
Coordinates 2579860..2580147 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag BVH57_RS12995 Protein ID WP_005714439.1
Coordinates 2579604..2579876 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVH57_RS12975 2575203..2576303 - 1101 WP_005709638.1 metalloregulator ArsR/SmtB family transcription factor -
BVH57_RS12980 2576416..2577789 + 1374 WP_005714442.1 MFS transporter -
BVH57_RS12985 2577952..2579115 - 1164 WP_005709634.1 MFS transporter -
BVH57_RS12990 2579197..2579490 - 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
BVH57_RS12995 2579604..2579876 + 273 WP_005714439.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BVH57_RS13000 2579860..2580147 + 288 WP_005709630.1 type II toxin-antitoxin system YafQ family toxin Toxin
BVH57_RS13005 2580371..2581780 + 1410 WP_005714438.1 3'-5' exonuclease -
BVH57_RS13010 2581998..2582177 + 180 WP_005709626.1 hypothetical protein -
BVH57_RS13015 2582288..2582716 + 429 WP_005714437.1 OsmC family protein -
BVH57_RS13020 2582910..2583929 + 1020 WP_005709622.1 dihydroxyacetone kinase subunit DhaK -
BVH57_RS13025 2583916..2584497 + 582 WP_005709619.1 dihydroxyacetone kinase subunit L -
BVH57_RS13030 2584531..2584899 + 369 WP_005686376.1 PTS-dependent dihydroxyacetone kinase phosphotransferase subunit DhaM -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-90)

Antitoxin

(6-67)


Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10888.77 Da        Isoelectric Point: 10.9032

>T74702 WP_005709630.1 NZ_CP020464:2579860-2580147 [Lacticaseibacillus rhamnosus]
MMLTINRTRTFKRQFKHLLRQGKDMTKLATAIDTLQRQDRVKLASLHDHALKGAHSGERALRVAPDWLLVYKVDAEALIL
MLLATGTHRDTLNIE

Download         Length: 288 bp

>T74702 NZ_CP020464:2579860-2580147 [Lacticaseibacillus rhamnosus]
ATGATGTTGACGATTAATCGCACGCGCACTTTCAAACGACAATTTAAACATCTTCTTAGGCAAGGTAAAGATATGACGAA
ACTTGCAACTGCAATTGATACTTTGCAGCGTCAAGATCGTGTAAAATTAGCTTCTTTACACGACCATGCTTTAAAGGGTG
CTCACAGCGGCGAACGAGCATTGCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTA
ATGCTTCTTGCAACAGGCACACACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10073.49 Da        Isoelectric Point: 5.1154

>AT74702 WP_005714439.1 NZ_CP020464:2579604-2579876 [Lacticaseibacillus rhamnosus]
METKSRISVRIDTKTKERALHVLNSMGLDMSSAINMYLKRIGDTGELPFTPEMSFADQLQAAEADVKAGRTKSFKTVDAL
MKDLYNDVDD

Download         Length: 273 bp

>AT74702 NZ_CP020464:2579604-2579876 [Lacticaseibacillus rhamnosus]
ATGGAAACAAAATCCCGTATCAGCGTGCGAATTGATACCAAAACCAAAGAACGGGCTCTCCATGTCCTCAATAGCATGGG
ACTAGATATGTCCTCAGCTATTAACATGTATTTGAAACGCATTGGTGACACTGGTGAGTTGCCATTTACACCTGAAATGT
CGTTCGCCGATCAGCTTCAAGCTGCAGAAGCTGATGTTAAAGCGGGACGAACTAAGAGCTTCAAGACCGTTGATGCCCTG
ATGAAGGATTTATACAATGATGTTGACGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References