Detailed information of TA system TA074696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1406207..1406719
• Replicon: chromosome
• Accession: NZ_CP020451
• Organism: Streptococcus salivarius strain FDAARGOS_259

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T0T9T6
• Locus tag: A6J87_RS07265
• Protein ID: WP_021143706.1
• Coordinates: 1406465..1406719 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: A6J87_RS07260
• Protein ID: WP_105257737.1
• Coordinates: 1406207..1406461 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J87_RS07225	1401508..1401825	+	318	WP_002884193.1	ribosome assembly RNA-binding protein YhbY	-
A6J87_RS07230	1401931..1402563	+	633	WP_021143701.1	nicotinate-nucleotide adenylyltransferase	-
A6J87_RS07235	1402560..1403153	+	594	WP_070575460.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
A6J87_RS07240	1403157..1403657	+	501	WP_070575463.1	cysteine hydrolase	-
A6J87_RS07245	1403672..1404022	+	351	WP_002891669.1	ribosome silencing factor	-
A6J87_RS07250	1404227..1404967	+	741	WP_004183284.1	class I SAM-dependent methyltransferase	-
A6J87_RS07255	1404974..1406065	+	1092	WP_070575465.1	nucleotidyltransferase	-
A6J87_RS07260	1406207..1406461	+	255	WP_105257737.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A6J87_RS07265	1406465..1406719	+	255	WP_021143706.1	Txe/YoeB family addiction module toxin	Toxin
A6J87_RS07270	1407423..1409528	+	2106	WP_060971902.1	ATP-dependent Clp protease ATP-binding subunit	-
A6J87_RS07275	1410102..1410737	+	636	WP_080610810.1	DUF4230 domain-containing protein	-
A6J87_RS07280	1410756..1411484	+	729	WP_080610809.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1411662..1412918	1256

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10141.64 Da
• Isoelectric Point: 8.8499

>T74696 WP_021143706.1 NZ_CP020451:1406465-1406719 [Streptococcus salivarius]
MLLTFTEDAWMDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T74696 NZ_CP020451:1406465-1406719 [Streptococcus salivarius]
ATGTTACTCACTTTCACTGAAGATGCATGGATGGATTATTGTTATTGGCAAAATCAGGATAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAACCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGTGTCGCCTTTCTCTCTTTT
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.04 Da
• Isoelectric Point: 5.1786

>AT74696 WP_105257737.1 NZ_CP020451:1406207-1406461 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVKNKELSDKVLRGMAQVRAGETQEH
ALKE

Nucleotide

• Length: 255 bp

>AT74696 NZ_CP020451:1406207-1406461 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTGAAGGATTATATGAAAAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAGTGGGATAGCATTCAAGAAACATTGC
GTATTGTTAAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAGCAT
GCACTAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: A0A074IRU5