74695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 218349..219006 Replicon chromosome
Accession NZ_CP020451
Organism Streptococcus salivarius strain FDAARGOS_259

Toxin (Protein)


Gene name higB Uniprot ID A0A1V0H5E1
Locus tag A6J87_RS00990 Protein ID WP_073950173.1
Coordinates 218653..219006 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1V0H5D4
Locus tag A6J87_RS00985 Protein ID WP_073950175.1
Coordinates 218349..218651 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J87_RS00970 215091..215990 - 900 WP_064523419.1 Rpn family recombination-promoting nuclease/putative transposase -
A6J87_RS00975 216154..217848 - 1695 WP_073950179.1 DUF2075 domain-containing protein -
A6J87_RS00980 217858..218187 - 330 WP_070846935.1 nucleotide pyrophosphohydrolase -
A6J87_RS00985 218349..218651 - 303 WP_073950175.1 helix-turn-helix transcriptional regulator Antitoxin
A6J87_RS00990 218653..219006 - 354 WP_073950173.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J87_RS00995 219244..220008 - 765 WP_073950171.1 SDR family NAD(P)-dependent oxidoreductase -
A6J87_RS01000 220040..221197 - 1158 WP_080611428.1 DUF2974 domain-containing protein -
A6J87_RS01005 221307..221933 + 627 WP_080610400.1 Pr6Pr family membrane protein -
A6J87_RS01010 221970..222812 - 843 WP_080611429.1 Cof-type HAD-IIB family hydrolase -
A6J87_RS01015 222964..223353 + 390 WP_080611232.1 sodium transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 14146.56 Da        Isoelectric Point: 10.4188

>T74695 WP_073950173.1 NZ_CP020451:c219006-218653 [Streptococcus salivarius]
MYPIHFYKDRNGHEPVREYIETLYINSSKDSRIKLHKIQDYLTMLKNRGTMIGEPFIKHLEGDIWELRPLRDRILFAAWL
DDGFILLHHFVKKTRKTPRRELMKAQKALDDIRKRGL

Download         Length: 354 bp

>T74695 NZ_CP020451:c219006-218653 [Streptococcus salivarius]
ATGTATCCTATTCATTTTTATAAAGATAGAAATGGACATGAACCTGTTAGAGAGTATATTGAAACATTATACATAAATTC
AAGCAAAGATTCTAGAATCAAATTACATAAAATTCAAGACTACCTGACTATGTTAAAAAATAGAGGAACCATGATTGGTG
AACCATTCATTAAACATTTGGAAGGAGATATTTGGGAACTAAGACCCTTGAGGGATAGAATTTTATTTGCAGCATGGCTA
GATGATGGTTTTATTTTGCTTCATCATTTTGTTAAAAAAACAAGAAAGACTCCAAGGCGTGAGCTGATGAAGGCTCAAAA
AGCTTTAGATGATATTAGAAAGCGAGGATTGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10993.95 Da        Isoelectric Point: 10.0976

>AT74695 WP_073950175.1 NZ_CP020451:c218651-218349 [Streptococcus salivarius]
MVREKNPAIGSSWDDLQKTIFTKEEIAASELRVALMLEIIDARKKQGISQKKLEELSGVKQPVIARMETGKTAPQLDTVL
KILASLGKTLAVVPLDSHVK

Download         Length: 303 bp

>AT74695 NZ_CP020451:c218651-218349 [Streptococcus salivarius]
ATGGTTCGAGAAAAGAATCCAGCAATTGGAAGTAGTTGGGATGATTTACAGAAAACTATTTTCACTAAAGAGGAAATCGC
GGCAAGTGAACTCCGTGTTGCACTGATGCTTGAGATTATTGATGCTCGTAAAAAACAAGGTATTTCCCAAAAGAAACTTG
AAGAGTTAAGTGGTGTCAAACAACCTGTTATCGCACGTATGGAGACTGGGAAAACGGCACCCCAGTTAGATACGGTTCTT
AAAATCCTAGCAAGTCTAGGAAAGACATTGGCGGTAGTCCCACTTGACTCCCATGTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0H5E1

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0H5D4

References