Detailed information of TA system TA074655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 1377140..1378488
• Replicon: chromosome
• Accession: NZ_CP020411
• Organism: Haemophilus influenzae strain FDAARGOS_199

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: A6J38_RS06765
• Protein ID: WP_005694624.1
• Coordinates: 1377457..1378488 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2S9RZQ1
• Locus tag: A6J38_RS06760
• Protein ID: WP_005672747.1
• Coordinates: 1377140..1377460 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J38_RS06720	1372565..1372843	+	279	WP_005661211.1	cell division protein FtsB	-
A6J38_RS06725	1372843..1373520	+	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
A6J38_RS06730	1373517..1373993	+	477	WP_005687916.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
A6J38_RS06735	1374295..1374729	-	435	WP_005694618.1	D-tyrosyl-tRNA(Tyr) deacylase	-
A6J38_RS06740	1374726..1375166	-	441	WP_005694621.1	FMN-binding protein MioC	-
A6J38_RS06745	1375263..1375481	-	219	WP_005650820.1	cell division protein ZapB	-
A6J38_RS06750	1375643..1376644	+	1002	WP_005694623.1	class II fructose-bisphosphatase	-
A6J38_RS06755	1376844..1377152	+	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
A6J38_RS06760	1377140..1377460	+	321	WP_005672747.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
A6J38_RS06765	1377457..1378488	+	1032	WP_005694624.1	type II toxin-antitoxin system HipA family toxin	Toxin
A6J38_RS06770	1378572..1380230	-	1659	WP_005667625.1	thiol reductant ABC exporter subunit CydC	-
A6J38_RS06775	1380223..1381968	-	1746	WP_005694625.1	ABC transporter ATP-binding protein/permease	-
A6J38_RS06780	1382017..1382181	-	165	WP_005694626.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39832.46 Da
• Isoelectric Point: 6.4335

>T74655 WP_005694624.1 NZ_CP020411:1377457-1378488 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTDNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVITRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Nucleotide

• Length: 1032 bp

>T74655 NZ_CP020411:1377457-1378488 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGACAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAACGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTAAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12453.12 Da
• Isoelectric Point: 5.9670

>AT74655 WP_005672747.1 NZ_CP020411:1377140-1377460 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT74655 NZ_CP020411:1377140-1377460 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2S9RZQ1