Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-DUF971
Location 578565..579154 Replicon chromosome
Accession NZ_CP020411
Organism Haemophilus influenzae strain FDAARGOS_199

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag A6J38_RS02945 Protein ID WP_005693946.1
Coordinates 578855..579154 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag A6J38_RS02940 Protein ID WP_005643896.1
Coordinates 578565..578858 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J38_RS02905 573705..574634 - 930 WP_005656626.1 universal stress protein UspE -
A6J38_RS02910 574756..575529 - 774 WP_005662331.1 fumarate/nitrate reduction transcriptional regulator Fnr -
A6J38_RS02920 576041..576955 + 915 WP_005693942.1 site-specific integrase -
A6J38_RS02925 576956..577240 - 285 WP_005693943.1 hypothetical protein -
A6J38_RS02930 577528..578103 - 576 WP_005693944.1 antA/AntB antirepressor family protein -
A6J38_RS02935 578172..578534 + 363 WP_050396694.1 hypothetical protein -
A6J38_RS02940 578565..578858 - 294 WP_005643896.1 putative addiction module antidote protein Antitoxin
A6J38_RS02945 578855..579154 - 300 WP_005693946.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J38_RS02950 579515..580183 + 669 WP_005693947.1 Bro-N domain-containing protein -
A6J38_RS09135 580259..580396 + 138 WP_165442161.1 hypothetical protein -
A6J38_RS02955 580520..580876 + 357 WP_005650535.1 phage holin, lambda family -
A6J38_RS02960 580845..581447 + 603 WP_005693948.1 glycoside hydrolase family 19 protein -
A6J38_RS02965 581440..581715 + 276 WP_005693950.1 DUF2570 family protein -
A6J38_RS02970 581627..581908 + 282 WP_005693951.1 hypothetical protein -
A6J38_RS02975 582036..582557 + 522 WP_010869207.1 Rha family transcriptional regulator -
A6J38_RS02980 582567..583082 + 516 WP_005693952.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 565595..590281 24686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-89)

Antitoxin

Uncharacterized protein HI1420

(3-95)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11169.05 Da        Isoelectric Point: 10.4328

>T74651 WP_005693946.1 NZ_CP020411:c579154-578855 [Haemophilus influenzae]
MTIQIKTTLTFDSWLSKLKNLRAKAKINARIKRLQFGNFGDIKSVNDGIFELRIDEGQGYRVYLKNQNGVLVILLCGGDK
STQDKDIKQAKLLAQELGL

Download         Length: 300 bp

>T74651 NZ_CP020411:c579154-578855 [Haemophilus influenzae]
ATGACAATCCAAATCAAAACCACTCTGACATTTGATTCTTGGTTAAGCAAACTAAAAAACTTGCGTGCCAAAGCGAAAAT
AAACGCACGAATTAAACGCTTACAGTTCGGCAACTTTGGTGATATCAAAAGCGTGAATGATGGGATTTTTGAATTACGGA
TTGATGAAGGTCAAGGTTATCGAGTTTATCTTAAAAACCAGAATGGCGTATTAGTGATTTTACTTTGTGGCGGAGATAAA
TCCACACAAGATAAAGATATTAAACAAGCAAAACTTCTCGCACAGGAGCTAGGATTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10889.38 Da        Isoelectric Point: 4.4488

>AT74651 WP_005643896.1 NZ_CP020411:c578858-578565 [Haemophilus influenzae]
MTEQLKDFDVAEHLTSEEEIQLYLNEILQEDNIELILSALGDIARARNMSQIARDAGISREGLYKALSGTGNPTFATVMK
VMKALNLQFQVQQSRFA

Download         Length: 294 bp

>AT74651 NZ_CP020411:c578858-578565 [Haemophilus influenzae]
ATGACTGAACAATTAAAAGACTTTGATGTGGCAGAACACCTCACTTCTGAAGAAGAAATTCAACTTTACCTTAATGAAAT
TCTACAAGAAGATAATATTGAGCTTATTTTATCCGCCCTTGGCGACATAGCCCGTGCGCGTAACATGAGCCAAATCGCAC
GTGATGCAGGAATAAGCCGAGAAGGTCTTTATAAAGCCTTATCTGGCACGGGCAATCCTACTTTTGCTACTGTAATGAAA
GTAATGAAAGCCTTAAATTTACAATTCCAAGTGCAACAATCTCGATTCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References