Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/-
Location 1509962..1510551 Replicon chromosome
Accession NC_000907
Organism Haemophilus influenzae Rd KW20

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HI_RS07320 Protein ID WP_005693946.1
Coordinates 1509962..1510261 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HI_RS07325 Protein ID WP_005643896.1
Coordinates 1510258..1510551 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI_RS07285 (HI1411) 1506035..1506550 - 516 WP_005693952.1 terminase small subunit -
HI_RS07290 (HI1412) 1506560..1507081 - 522 WP_010869207.1 Rha family transcriptional regulator -
HI_RS07295 (HI1413) 1507209..1507490 - 282 WP_005693951.1 hypothetical protein -
HI_RS07300 (HI1414) 1507402..1507677 - 276 WP_005693950.1 DUF2570 family protein -
HI_RS07305 (HI1415) 1507670..1508272 - 603 WP_005693948.1 glycoside hydrolase family 19 protein -
HI_RS07310 (HI1416) 1508241..1508597 - 357 WP_005650535.1 phage holin, lambda family -
HI_RS08995 1508721..1508858 - 138 WP_165442161.1 hypothetical protein -
HI_RS07315 (HI1418) 1508934..1509601 - 668 Protein_1398 hypothetical protein -
HI_RS07320 (HI1419) 1509962..1510261 + 300 WP_005693946.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HI_RS07325 (HI1420) 1510258..1510551 + 294 WP_005643896.1 putative addiction module antidote protein Antitoxin
HI_RS07330 (HI_1421) 1510582..1510944 - 363 WP_050396694.1 hypothetical protein -
HI_RS07335 (HI1422) 1511013..1511588 + 576 WP_005693944.1 P22AR C-terminal domain-containing protein -
HI_RS07340 (HI1423) 1511874..1512158 + 285 WP_005693943.1 hypothetical protein -
HI_RS07345 (HI1424) 1512159..1513073 - 915 WP_005693942.1 site-specific integrase -
HI_RS07355 (HI1425) 1513585..1514358 + 774 WP_005662331.1 fumarate/nitrate reduction transcriptional regulator Fnr -
HI_RS07360 (HI1426) 1514479..1515408 + 930 WP_010869209.1 universal stress protein UspE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1498837..1529727 30890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-89)

Antitoxin

Uncharacterized protein HI1420

(3-95)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11169.05 Da        Isoelectric Point: 10.4328

>T20121 WP_005693946.1 NC_000907:1509962-1510261 [Haemophilus influenzae Rd KW20]
MTIQIKTTLTFDSWLSKLKNLRAKAKINARIKRLQFGNFGDIKSVNDGIFELRIDEGQGYRVYLKNQNGVLVILLCGGDK
STQDKDIKQAKLLAQELGL

Download         Length: 300 bp

>T20121 NC_000907:1509962-1510261 [Haemophilus influenzae Rd KW20]
ATGACAATCCAAATCAAAACCACTCTGACATTTGATTCTTGGTTAAGCAAACTAAAAAACTTGCGTGCCAAAGCGAAAAT
AAACGCACGAATTAAACGCTTACAGTTCGGCAACTTTGGTGATATCAAAAGCGTGAATGATGGGATTTTTGAATTACGGA
TTGATGAAGGTCAAGGTTATCGAGTTTATCTTAAAAACCAGAATGGCGTATTAGTGATTTTACTTTGTGGCGGAGATAAA
TCCACACAAGATAAAGATATTAAACAAGCAAAACTTCTCGCACAGGAGCTAGGATTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10889.38 Da        Isoelectric Point: 4.4488

>AT20121 WP_005643896.1 NC_000907:1510258-1510551 [Haemophilus influenzae Rd KW20]
MTEQLKDFDVAEHLTSEEEIQLYLNEILQEDNIELILSALGDIARARNMSQIARDAGISREGLYKALSGTGNPTFATVMK
VMKALNLQFQVQQSRFA

Download         Length: 294 bp

>AT20121 NC_000907:1510258-1510551 [Haemophilus influenzae Rd KW20]
ATGACTGAACAATTAAAAGACTTTGATGTGGCAGAACACCTCACTTCTGAAGAAGAAATTCAACTTTACCTTAATGAAAT
TCTACAAGAAGATAATATTGAGCTTATTTTATCCGCCCTTGGCGACATAGCCCGTGCGCGTAACATGAGCCAAATCGCAC
GTGATGCAGGAATAAGCCGAGAAGGTCTTTATAAAGCCTTATCTGGCACGGGCAATCCTACTTTTGCTACTGTAATGAAA
GTAATGAAAGCCTTAAATTTACAATTCCAAGTGCAACAATCTCGATTCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References