Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4116864..4117525 Replicon chromosome
Accession NZ_CP020409
Organism Yersinia sp. FDAARGOS_228

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A6J67_RS19125 Protein ID WP_050297771.1
Coordinates 4116864..4117190 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A6J67_RS19130 Protein ID WP_042569385.1
Coordinates 4117229..4117525 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J67_RS19080 4112984..4113736 + 753 WP_032908027.1 HAD-IIA family hydrolase -
A6J67_RS19090 4114218..4115882 + 1665 WP_050297770.1 asparagine synthase B -
A6J67_RS19125 4116864..4117190 + 327 WP_050297771.1 hypothetical protein Toxin
A6J67_RS19130 4117229..4117525 + 297 WP_042569385.1 helix-turn-helix domain-containing protein Antitoxin
A6J67_RS19135 4117665..4118846 - 1182 WP_050074553.1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase -
A6J67_RS19140 4119072..4120496 + 1425 WP_042569384.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
A6J67_RS19145 4120793..4121866 + 1074 WP_172668594.1 PhoH family protein -
A6J67_RS19150 4121863..4122336 + 474 WP_032905735.1 rRNA maturation RNase YbeY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12585.46 Da        Isoelectric Point: 9.4625

>T74648 WP_050297771.1 NZ_CP020409:4116864-4117190 [Yersinia sp. FDAARGOS_228]
MDFLEFVETPIFSRRRAELMSDDDFQQFQTYLLNNPQSGDTISKTGGYQKIRWGGLQRGKRGGIRVIYFVVAQRCRIWLL
LAYSKNEKDDLSESEKTVLKMITAKLDL

Download         Length: 327 bp

>T74648 NZ_CP020409:4116864-4117190 [Yersinia sp. FDAARGOS_228]
ATGGATTTCCTTGAGTTTGTAGAAACACCGATTTTTAGTCGGCGTCGAGCAGAACTAATGTCAGATGATGACTTTCAACA
ATTTCAGACTTACCTACTTAATAATCCTCAGTCTGGAGACACAATAAGCAAAACCGGGGGCTATCAAAAAATTCGATGGG
GTGGTTTGCAGCGAGGTAAACGCGGTGGTATCAGAGTTATCTATTTTGTTGTGGCCCAACGTTGTCGCATCTGGTTATTG
TTGGCTTATTCTAAAAATGAAAAAGATGATCTGTCTGAATCAGAAAAAACCGTATTGAAAATGATAACCGCTAAACTCGA
TTTATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11268.16 Da        Isoelectric Point: 7.3203

>AT74648 WP_042569385.1 NZ_CP020409:4117229-4117525 [Yersinia sp. FDAARGOS_228]
MKKELFDDLVESMNYMVAAEKGESRPKAEQIHRHPLPDVKLLRLSSGMKQEEFADIVGVSKGLVQSWEQHRRIPSGSALK
LLMMIERNPNIIEELRVL

Download         Length: 297 bp

>AT74648 NZ_CP020409:4117229-4117525 [Yersinia sp. FDAARGOS_228]
ATGAAAAAAGAACTCTTTGATGATCTGGTTGAAAGCATGAATTACATGGTCGCGGCTGAAAAAGGTGAATCACGCCCTAA
AGCAGAACAAATTCACCGTCACCCCTTACCCGATGTAAAATTATTGCGACTTTCCTCCGGCATGAAACAAGAAGAGTTCG
CAGATATCGTCGGTGTTAGCAAGGGATTGGTTCAAAGCTGGGAGCAACATCGGAGGATCCCTTCAGGTTCAGCATTAAAG
CTATTGATGATGATAGAAAGAAACCCGAATATTATTGAAGAATTACGCGTCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References