Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 902251..902976 Replicon chromosome
Accession NZ_CP020405
Organism Pasteurella multocida strain FDAARGOS_218

Toxin (Protein)


Gene name higB Uniprot ID A0A8E2A4A3
Locus tag A6J57_RS04395 Protein ID WP_032854112.1
Coordinates 902650..902976 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A6J57_RS04390 Protein ID WP_005757699.1
Coordinates 902251..902577 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J57_RS04370 897689..898720 + 1032 WP_005757705.1 hypothetical protein -
A6J57_RS04375 898958..899965 + 1008 WP_005755103.1 hypothetical protein -
A6J57_RS04380 900016..900618 + 603 WP_005757703.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
A6J57_RS04385 900677..902197 + 1521 WP_005757701.1 DUF560 domain-containing protein -
A6J57_RS04390 902251..902577 - 327 WP_005757699.1 HigA family addiction module antidote protein Antitoxin
A6J57_RS04395 902650..902976 - 327 WP_032854112.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J57_RS04400 903134..903610 + 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
A6J57_RS04405 903684..904553 - 870 WP_005757694.1 VirK/YbjX family protein -
A6J57_RS04410 904664..905281 + 618 WP_005755089.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
A6J57_RS04415 905389..906918 + 1530 WP_005757692.1 YifB family Mg chelatase-like AAA ATPase -
A6J57_RS04420 906972..907658 - 687 WP_005757690.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12832.64 Da        Isoelectric Point: 9.6705

>T74607 WP_032854112.1 NZ_CP020405:c902976-902650 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNSPKITELRLDKHQYRL

Download         Length: 327 bp

>T74607 NZ_CP020405:c902976-902650 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGTG
ATTTACGAAGTCCACCTGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAGTATCGTTTAATATTTAAATATAAAGAAAGTAATTCTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT74607 WP_005757699.1 NZ_CP020405:c902577-902251 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT74607 NZ_CP020405:c902577-902251 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCAAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTCGTCTATTGATCAGCATAATCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References