Detailed information of TA system TA074602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1491306..1492029
• Replicon: chromosome
• Accession: NZ_CP020398
• Organism: Burkholderia multivorans strain FDAARGOS_246

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: A8H40_RS23655
• Protein ID: WP_006409059.1
• Coordinates: 1491709..1492029 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: A8H40_RS23650
• Protein ID: WP_006403504.1
• Coordinates: 1491306..1491707 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H40_RS23630	1487008..1488360	-	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-
A8H40_RS23635	1488357..1489418	-	1062	WP_006403500.1	LLM class flavin-dependent oxidoreductase	-
A8H40_RS23640	1489450..1490391	-	942	WP_006409064.1	ABC transporter substrate-binding protein	-
A8H40_RS23645	1490457..1491017	-	561	WP_006409062.1	GNAT family N-acetyltransferase	-
A8H40_RS23650	1491306..1491707	-	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
A8H40_RS23655	1491709..1492029	-	321	WP_006409059.1	type II toxin-antitoxin system MqsR family toxin	Toxin
A8H40_RS23660	1492123..1493157	-	1035	WP_006397017.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
A8H40_RS23665	1493258..1493530	-	273	WP_006403506.1	hypothetical protein	-
A8H40_RS23670	1493736..1495277	-	1542	WP_167338149.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (20-105)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12024.04 Da
• Isoelectric Point: 9.0721

>T74602 WP_006409059.1 NZ_CP020398:c1492029-1491709 [Burkholderia multivorans]
MVTLAHGYLWKSERRTASCRVKALIEAGKVRLTASAVIGARLMGFTEAEAIDVVRALTPFEFHKSMTTYADHTIWQDVYR
PCTMRGDVYLKLTVVDDVLIVSFKER

Nucleotide

• Length: 321 bp

>T74602 NZ_CP020398:c1492029-1491709 [Burkholderia multivorans]
TTGGTTACACTCGCGCATGGATACCTATGGAAAAGCGAACGCCGCACTGCAAGCTGCCGCGTCAAGGCGCTGATCGAAGC
CGGCAAGGTCCGCCTGACCGCAAGCGCCGTCATCGGCGCCCGCCTGATGGGCTTCACCGAAGCGGAAGCGATCGACGTGG
TGAGGGCGCTGACACCGTTCGAATTCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGG
CCTTGCACGATGCGCGGCGACGTGTACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATA
A

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT74602 WP_006403504.1 NZ_CP020398:c1491707-1491306 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT74602 NZ_CP020398:c1491707-1491306 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGTGCTGCCACGCTGGTCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACATCACCGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAGGTGAACGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTACGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCACCGCTGGCGCTCGTGAAGCTGCTGAAGATTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGTGCGGCAT
AA

Structures

Antitoxin

• AlphaFold DB: B9BI88