Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 713354..714011 Replicon chromosome
Accession NZ_CP020390
Organism Burkholderia thailandensis strain FDAARGOS_237

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A8H31_RS16690 Protein ID WP_043036475.1
Coordinates 713354..713686 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A8H31_RS16695 Protein ID WP_080868991.1
Coordinates 713694..714011 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H31_RS16665 708563..708844 + 282 WP_025369698.1 DUF2523 domain-containing protein -
A8H31_RS16670 708841..709746 + 906 WP_009910232.1 hypothetical protein -
A8H31_RS16675 709743..711131 + 1389 WP_025369697.1 hypothetical protein -
A8H31_RS16680 711598..712377 + 780 WP_043036474.1 hypothetical protein -
A8H31_RS16685 712725..713312 + 588 WP_043037179.1 site-specific integrase -
A8H31_RS16690 713354..713686 + 333 WP_043036475.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H31_RS16695 713694..714011 + 318 WP_080868991.1 helix-turn-helix domain-containing protein Antitoxin
A8H31_RS16700 714184..715692 + 1509 WP_043036477.1 hypothetical protein -
A8H31_RS16705 716065..717093 + 1029 WP_009910245.1 site-specific integrase -
A8H31_RS16710 717207..718172 - 966 Protein_653 IS256 family transposase -
A8H31_RS16715 718252..718812 + 561 Protein_654 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-100)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12746.79 Da        Isoelectric Point: 10.1361

>T74585 WP_043036475.1 NZ_CP020390:713354-713686 [Burkholderia thailandensis]
MKLDWTVVYYNERVKRDVFAFPAGILADYLRLLDLMQDFGADLRMPHSRAMGSGLFELRPKGREGIGRVFYCTHVGQQVV
VLHSFVKKTQETPQHELRIAQARLREVRNG

Download         Length: 333 bp

>T74585 NZ_CP020390:713354-713686 [Burkholderia thailandensis]
ATGAAACTTGATTGGACGGTCGTCTACTACAACGAACGGGTGAAGCGCGACGTTTTCGCGTTCCCCGCTGGGATTCTTGC
GGACTACCTCCGGCTGCTGGATCTGATGCAGGATTTCGGTGCGGATCTACGGATGCCGCATTCACGAGCAATGGGTAGCG
GGTTGTTTGAACTGCGTCCCAAGGGTAGGGAAGGTATCGGGCGGGTGTTCTATTGCACACATGTGGGGCAGCAAGTCGTT
GTGCTGCACTCCTTCGTCAAGAAGACGCAGGAAACGCCGCAACATGAATTGCGGATCGCCCAAGCACGGTTGAGAGAGGT
GCGTAATGGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11325.79 Da        Isoelectric Point: 10.2764

>AT74585 WP_080868991.1 NZ_CP020390:713694-714011 [Burkholderia thailandensis]
VKRVRAEGFNPVPHTADDTSRLLAGRNVKSAYDALEDEYTALRAILSARRDAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKRLVISFS

Download         Length: 318 bp

>AT74585 NZ_CP020390:713694-714011 [Burkholderia thailandensis]
GTGAAGCGCGTTCGCGCTGAGGGATTCAATCCGGTTCCGCACACAGCGGACGACACGTCGCGTCTGCTCGCCGGTCGTAA
CGTTAAGTCGGCGTATGACGCGCTGGAGGATGAGTACACCGCGCTGCGAGCTATCTTATCTGCGCGGCGCGATGCCGGTC
TGACGCAGGCTCAGATTGCGGAGCGGATGGGTACGACCGCATCGGCGGTTTCGCGGCTAGAGGCTTCGCTGTCGAGTGAA
AAGCATTCACCGTCATTTGCGACACTGCGTAAATATGCGGCTGCATGTGGCAAGCGATTGGTTATTTCATTTTCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References