Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4344177..4344845 Replicon chromosome
Accession NZ_CP020388
Organism Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A8H26_RS20585 Protein ID WP_106912900.1
Coordinates 4344177..4344530 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A8H26_RS20590 Protein ID WP_045287872.1
Coordinates 4344534..4344845 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H26_RS20555 4339276..4339695 - 420 WP_043083055.1 RNA polymerase-binding protein DksA -
A8H26_RS20560 4339803..4340042 + 240 WP_043086484.1 hypothetical protein -
A8H26_RS20565 4340045..4341232 - 1188 WP_106912899.1 GTP-binding protein -
A8H26_RS20570 4341593..4341919 + 327 WP_106913037.1 hypothetical protein -
A8H26_RS20575 4342024..4343478 + 1455 WP_043083053.1 AMP nucleosidase -
A8H26_RS20580 4343516..4343995 - 480 WP_043083052.1 GNAT family N-acetyltransferase -
A8H26_RS20585 4344177..4344530 + 354 WP_106912900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H26_RS20590 4344534..4344845 + 312 WP_045287872.1 XRE family transcriptional regulator Antitoxin
A8H26_RS20600 4345063..4346451 - 1389 WP_043083047.1 APC family permease -
A8H26_RS20605 4346718..4348136 - 1419 WP_045287871.1 glutamine synthetase family protein -
A8H26_RS20610 4348349..4349113 + 765 WP_106913038.1 gamma-glutamyl-gamma-aminobutyrate hydrolase -
A8H26_RS20615 4349139..4349696 + 558 WP_043083043.1 HTH-type transcriptional regulator PuuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(21-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13817.79 Da        Isoelectric Point: 7.9969

>T74578 WP_106912900.1 NZ_CP020388:4344177-4344530 [Pluralibacter gergoviae]
VWNIQVTETYKLWHQALSAKDQARVLAMLDLLEKEGPRLGRPYADTIKGSRFSNMKELRIQRRGEPLRIFYVFSPEREGI
LLCAGNKSGDDKRFYDIMIPLADEEYTEYLNHFYQSR

Download         Length: 354 bp

>T74578 NZ_CP020388:4344177-4344530 [Pluralibacter gergoviae]
GTGTGGAACATTCAGGTAACAGAAACATACAAACTCTGGCATCAGGCGCTGAGCGCTAAAGACCAGGCACGGGTACTTGC
CATGCTCGACCTGCTGGAAAAGGAGGGTCCCCGGCTCGGCAGGCCGTATGCCGATACAATAAAAGGCTCCCGCTTCAGCA
ATATGAAAGAGCTCAGGATCCAGCGCCGGGGCGAGCCGCTGCGCATTTTTTACGTCTTCTCACCTGAACGCGAAGGCATC
CTGCTCTGTGCAGGCAACAAGTCAGGCGACGATAAGCGGTTTTATGACATCATGATCCCGCTCGCCGATGAAGAATACAC
TGAATATCTCAACCATTTTTATCAGTCGAGGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11553.36 Da        Isoelectric Point: 5.2078

>AT74578 WP_045287872.1 NZ_CP020388:4344534-4344845 [Pluralibacter gergoviae]
MVTTLKQLRAETTPEVLAEADALYQELLLEYNLAKLREMVNKTQQEMADSLGIKQPTLAGMEKKGNDIKLSSLKRYVEAA
GCRLNLDIELPDGTHCAFKLSER

Download         Length: 312 bp

>AT74578 NZ_CP020388:4344534-4344845 [Pluralibacter gergoviae]
ATGGTAACAACACTGAAGCAGCTGCGGGCGGAAACGACGCCGGAAGTGCTCGCCGAAGCCGACGCCCTCTATCAGGAGCT
GCTGCTGGAGTACAACCTGGCGAAGCTGCGTGAGATGGTCAATAAGACCCAGCAGGAGATGGCCGACAGTCTGGGCATTA
AGCAGCCGACGCTTGCCGGCATGGAGAAAAAGGGCAACGACATCAAGCTCTCTTCCCTCAAACGCTACGTAGAGGCGGCG
GGCTGCCGGCTGAATCTGGATATCGAGCTGCCGGACGGCACGCACTGCGCGTTTAAGCTTTCGGAACGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References