Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1078535..1079141 Replicon chromosome
Accession NZ_CP020370
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag THSYN_RS04750 Protein ID WP_100918122.1
Coordinates 1078818..1079141 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag THSYN_RS04745 Protein ID WP_100918121.1
Coordinates 1078535..1078825 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS04725 1073696..1074037 - 342 WP_100918117.1 hypothetical protein -
THSYN_RS04730 1074037..1074774 - 738 WP_100918118.1 abortive infection family protein -
THSYN_RS04735 1074771..1077707 - 2937 WP_100918119.1 class I SAM-dependent DNA methyltransferase -
THSYN_RS04740 1077744..1078364 - 621 WP_157817460.1 hypothetical protein -
THSYN_RS04745 1078535..1078825 - 291 WP_100918121.1 helix-turn-helix domain-containing protein Antitoxin
THSYN_RS04750 1078818..1079141 - 324 WP_100918122.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
THSYN_RS04755 1079372..1081621 + 2250 WP_100918123.1 DNA topoisomerase IV subunit A -
THSYN_RS04760 1081836..1082128 + 293 Protein_942 AAA family ATPase -
THSYN_RS33445 1082143..1082343 - 201 Protein_943 Abi family protein -
THSYN_RS04770 1082347..1083063 - 717 WP_100918124.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1052004..1089637 37633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(9-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12055.92 Da        Isoelectric Point: 7.8794

>T74440 WP_100918122.1 NZ_CP020370:c1079141-1078818 [Candidatus Thiodictyon syntrophicum]
MVFIELPIFVRCAANIFSDEDLAELQRTLLENPTAGDLIPGGRGLRKVRMPLQGRGKRGGARVIYYHWLSKEQCYLVYAF
TKNAAADLSKEQLHRLAAVIDEEINHG

Download         Length: 324 bp

>T74440 NZ_CP020370:c1079141-1078818 [Candidatus Thiodictyon syntrophicum]
ATGGTTTTCATCGAACTGCCGATTTTCGTTCGTTGCGCCGCCAATATCTTCTCGGATGAAGACCTCGCGGAACTGCAGCG
CACTCTGCTCGAAAACCCGACGGCGGGGGACCTGATTCCCGGTGGTCGCGGTCTCCGCAAAGTGAGAATGCCACTGCAGG
GGCGTGGAAAACGCGGCGGTGCGCGAGTGATCTACTACCACTGGCTCAGTAAGGAGCAGTGCTATCTGGTCTATGCCTTT
ACAAAGAACGCGGCGGCCGACCTAAGCAAGGAACAACTGCACCGGCTGGCCGCTGTCATTGATGAGGAGATAAATCATGG
ATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11057.72 Da        Isoelectric Point: 10.7784

>AT74440 WP_100918121.1 NZ_CP020370:c1078825-1078535 [Candidatus Thiodictyon syntrophicum]
MDNQQFDELLESVRDMGRHMRGETVAKTRVREFPDPDVKLIRERTGLSQTRFAYLIGVKPKTLQNWEQHRVRPTGPARAL
LRIVEANPGALTVLHP

Download         Length: 291 bp

>AT74440 NZ_CP020370:c1078825-1078535 [Candidatus Thiodictyon syntrophicum]
ATGGATAACCAGCAGTTTGACGAGTTGCTGGAGAGCGTCCGCGACATGGGTCGCCATATGCGCGGAGAGACCGTGGCCAA
AACACGGGTGCGCGAATTTCCGGACCCCGATGTCAAGCTGATCCGCGAGCGCACCGGCCTCAGCCAGACACGCTTTGCTT
ACCTGATCGGCGTCAAGCCCAAGACGCTGCAGAACTGGGAGCAGCATCGCGTGCGTCCGACCGGACCGGCCAGGGCGCTG
CTGCGGATTGTCGAGGCCAACCCTGGTGCCCTGACCGTACTGCACCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References