Detailed information of TA system TA074368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2427484..2428007
• Replicon: chromosome
• Accession: NZ_CP020354
• Organism: Staphylococcus aureus strain FORC59

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FORC59_RS12490
• Protein ID: WP_000074046.1
• Coordinates: 2427484..2427750 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: FORC59_RS12495
• Protein ID: WP_000587615.1
• Coordinates: 2427750..2428007 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC59_RS12470	2422883..2424067	-	1185	WP_000115415.1	MFS transporter	-
FORC59_RS12475	2424419..2425192	-	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
FORC59_RS12480	2425185..2425847	-	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
FORC59_RS12485	2426095..2427171	-	1077	WP_001076667.1	M42 family metallopeptidase	-
FORC59_RS12490	2427484..2427750	-	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
FORC59_RS12495	2427750..2428007	-	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC59_RS12500	2428365..2428829	+	465	WP_000736689.1	DUF1307 domain-containing protein	-
FORC59_RS12505	2428979..2430556	-	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
FORC59_RS12510	2430746..2431495	+	750	WP_049311723.1	hypothetical protein	-
FORC59_RS12515	2431719..2432912	-	1194	WP_000675403.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T74368 WP_000074046.1 NZ_CP020354:c2427750-2427484 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T74368 NZ_CP020354:c2427750-2427484 [Staphylococcus aureus]
ATGAGCAATTATACGGTTAAGATTAAAAATTCGGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAAAAGCC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACTGTAGATGATCGAAATAAAGAAGTATTAATA
TTATCGGCGTGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT74368 WP_000587615.1 NZ_CP020354:c2428007-2427750 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT74368 NZ_CP020354:c2428007-2427750 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGATGATTGGAAAAGTATACAAGAAACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGATAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2